Correction of the Cancer Therapy-Induced Anemia by the Grape Polyphenol Concentrate Enoant
Anticancer drugs do not possess sufficient specificity of action. Each cytostatic agent shows a wide spectrum of side effects that limit the efficacy of therapy and make the quality of life for a cancer patient worse. It forces scientists to search for new pharmacological agents for the correction/prevention of side effects. The polyphenolic compounds are naturally occurring phytochemicals that could be considered as potentially effective protectors of cancer chemotherapy toxicity. The main goal of the study was to study the ability of the grape polyphenol concentrated product Enoant to reduce hematotoxicity of cancer cytotoxic chemotherapy. In a preclinical study, the influence of Enoant on both hematotoxicity and the efficacy of cisplatin administered into Lewis lung carcinoma bearing mice was investigated. Enoant provided a significant protection against cisplatin-induced hematotoxicity by increasing red blood cell production and normalizing leukocyte levels in tumor-bearing mice. Enoant did not stimulate tumor growth and metastasis and did not reduce the efficacy of cisplatin-based therapy. Twenty cancer patients with anemia (averaged hemoglobin level was 85.8±0.8 g/L) were included in the clinical study. The correction of anemia during the first stage of investigation was conducted using either iron-containing drugs or erythropoietin. This gave the possibility to begin the course of cancer chemotherapy in 6.7±1.0 days when the hemoglobin level reached 94.6±1.8 g/L. Before the next course of anticancer treatment, the patients received Enoant (total dose of polyphenols was 5 g), that resulted in an 11 % increase of hemoglobin levels (p<0.05) up to 103.5±2.8 g/L. Thus, Enoant is an effective and safe agent for the treatment of cancer associated anemia. Enoant is well accepted by patients. Its safety, convenient oral form and palatability make it possible to carry out an effective correction of anemia at home.
KeywordsNegative Control Group Lewis Lung Carcinoma Tumor Cell Inoculation Erythropoietin Receptor Stimulate Tumor Growth
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