Mitochondrial BKCa Channel as a Target for Cardioprotection

  • František Kolář
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)


Large-conductance Ca2+-activated K+ channels (BKCa) are widely expressed in the plasma membrane of various types of cells and play important roles in many physiological processes by providing negative feedback for membrane depolarization and Ca2+ entry. Their mitochondrial counterparts located in the inner membrane are thought to be involved in the control of mitochondrial functions and serve as mediators of cytoprotection. This review briefly outlines basic knowledge of the molecular structure, sources of tissue diversity, and modulation of BKCa channels by endogenous and pharmacological agents. Particular attention is paid to the heart with an emphasis on the role mitochondrial BKCa channels in various forms of cardioprotection against acute ischemia/reperfusion injury.


Ventricular Myocytes Reactive Oxygen Species Formation H9c2 Cell BKCa Channel Dehydroabietic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Supported by the Czech Science Foundation (grant 303/12/1162).


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© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Developmental Cardiology, Institute of PhysiologyAcademy of Sciences of the Czech RepublicPragueCzech Republic

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