History of Surgery in Hilar Cholangiocarcinoma

  • S. H. Y. Lau
  • W. Y. Lau


In 1965, Dr. Gerald Klatskin reported in the American Journal of Medicine an article “Adenocarcinoma of the Hepatic Duct at Its Bifurcation Within the Porta Hepatis” [1]. The purpose of this report by Dr. Klatskin on 13 patients was “to draw attention to the unusual features of adenocarcinomas that arise in the hepatic duct at its bifurcation within the porta hepatis”. Thereafter, this tumor is named after him as Klatskin tumor. Actually, tumors of this type have been reported before him [2–7], but the distinctive manifestations of this tumor have not received sufficient emphasis. Dr. Klatskin stated in his paper that “tumors of this type are frequently overlooked during laparotomy …, death in this disease is usually attributable to hepatocellular failure and/or hepatobiliary infection secondary to unrelieved biliary obstruction rather than to massive invasion of the liver by tumor or to extrahepatic metastases, palliative surgery aimed at relieving biliary obstruction may restore the patient to a good state of health for a remarkable long period of time, and such palliation may be achieved by internal drainage of only one of the major intrahepatic bile ducts”. Some of these observations are still true even today on these tumors which for one reason or another cannot be resected!


Bile Duct Liver Resection Primary Sclerosing Cholangitis Orthotopic Liver Transplantation Hepatic Duct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht and People's Medical Publishing House 2013

Authors and Affiliations

  1. 1.Department of SurgeryQueen Elizabeth HospitalKowloonHong Kong
  2. 2.Faculty of MedicineThe Chinese University of Hong KongShatin, New TerritoriesHong Kong

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