Angiogenesis Modulation by Arachidonic Acid-derived Lipids: Positive and Negative Regulators of Angiogenesis

  • Robert C. Block
  • Murat Yalcin
  • Mathangi Srinivasan
  • Steve Georas
  • Shaker A. Mousa


Arachidonic acid-derived lipids such as 15 deoxy-PGJ2 or 15 epi-lipoxin A4 have been shown to be potent anti-angiogenesis agents regardless of the angiogenesis stimulus. Other arachidonic acid-derived mediators differentially stimulate angiogenesis and the balance among the different arachidonic acid metabolites along their interactions might play an important role in angiogenesis hemostasis in various angiogenesis-associated disorders.


Sudden Cardiac Death Human Umbilical Vein Endothelial Cell Lipid Mediator Vascular Endothelial Cell Growth Factor Epoxyeicosatrienoic Acid 
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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Robert C. Block
    • 1
    • 2
  • Murat Yalcin
    • 3
    • 4
  • Mathangi Srinivasan
    • 3
  • Steve Georas
    • 5
  • Shaker A. Mousa
    • 3
  1. 1.Department of Public Health SciencesUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Division of Cardiology, Department of MedicineUniversity of Rochester School of Medicine and DentistryRochesterUSA
  3. 3.The Pharmaceutical Research Institute at Albany College of Pharmacy and Health SciencesRensselaerUSA
  4. 4.Veterinary Medicine Faculty, Department of PhysiologyUludag UniversityGorukle, BursaTurkey
  5. 5.Division of Pulmonary and Critical Care Medicine, Department of MedicineUniversity of Rochester School of Medicine and DentistryRochesterUSA

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