Abstract
Cancer is the major health problem worldwide over a century. The development of cancer is a multi-step process, including initiation, promotion and progression. This process is driven by genetic changes, elicit transformation of initiated cell into cancerous cell with abnormal proliferative and invasive capabilities, and ultimately distant metastasis. Recent studies also exhibit that chronic inflammation is implicated in tumorigenesis by over-production of inflammatory mediators and creation of an inflammatory microenvironment. Prevention and treatment of cancer through dietary intervention has been considered as a rational approach. Convincing evidence shows regular consumption of fruit and vegetables is associated with reduced risks of cancer. Flavonoids are widely present in diet such as fruits and vegetables, they have been demonstrated a broad spectrum of biological activities for human health. They have been found to interfere with cancer development at different stage by targeting on various signaling molecules, genes, proteins and enzymes involved in tumorigenesis. Accumulating evidences report the potential of dietary flavonoids for both chemopreventive and chemotherapeutic effects which act on regulation of redox status, cellular proliferation, differentiation, programmed cell death, inflammation angiogenesis and metastasis. Some of them display synergy effect in combination of conventional therapies for drug-resistant cancer cells. In this chapter, we summarize recent knowledge and the underlying mechanism on chemopreventive and chemotherapeutic activities of dietary flavonoids that may offer effective approach for the control of cancer incidence.
Keywords
- Focal Adhesion Kinase
- Aberrant Crypt Focus
- Human Ovarian Cancer Cell
- Cancer Chemoprevention
- Dietary Flavonoid
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Pan, MH., Lai, CS., Wu, JC., Ho, CT. (2013). Effect of Flavonoids from Fruits and Vegetables in the Prevention and Treatment of Cancer. In: Cho, W. (eds) Cancer Chemoprevention and Treatment by Diet Therapy. Evidence-based Anticancer Complementary and Alternative Medicine, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6443-9_2
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Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-6442-2
Online ISBN: 978-94-007-6443-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)