Cardiolipin-Mediated Cellular Signaling

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 991)

Abstract

This review focuses on recent studies showing that cardiolipin (CL), a unique mitochondrial phospholipid, regulates many cellular functions and signaling pathways, both inside and outside the mitochondria. Inside the mitochondria, CL is a critical target of mitochondrial generated reactive oxygen species (ROS) and regulates signaling events related to apoptosis and aging. CL deficiency causes perturbation of signaling pathways outside the mitochondria, including the PKC-Slt2 cell integrity pathway and the high osmolarity glycerol (HOG) pathway, and is a key player in the cross-talk between the mitochondria and the vacuole. Understanding these connections may shed light on the pathology of Barth syndrome, a disorder of CL remodeling.

Keywords

Cardiolipin Phosphatidylglycerol Cellular signaling Apoptosis Cell wall biogenesis Mitophagy Mitochondria Vacuolar function Reactive oxygen species Anionic phospholipids Barth syndrome 

Notes

Acknowledgements

The Greenberg laboratory acknowledges support from the National Institutes of Health (R21 HL 084218) and the Barth Syndrome Foundation (BSF) to M.L.G., and Wayne State University Graduate Enhancement Research Funds to V.A.P.

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© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Biological SciencesWayne State UniversityDetroitUSA

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