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Experimental (Preclinical) Studies and Clinical Trials of Adipose Tissue-Derived Mesenchymal Stem Cells for Autoimmune Diseases

  • Eun Wha Choi
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 10)

Abstract

Mesenchymal stem cells (MSCs) are considered attractive therapeutic tools for the treatment of various diseases, including autoimmune disease. MSCs display many advantageous properties such as immunomodulation, capacity for differentiation and transdifferentiation, homing activity, and paracrine effects. Further, adipose tissue-derived MSCs (ASCs) are regarded an ideal source of these stem cells because of their plentiful supply, availability, non-immunogenic properties, and minimal ethical considerations as well as the fact that their capacity for proliferation and differentiation is less likely to be affected by aging. In the few preclinical studies and clinical trials that have been performed, treatment with ASCs have ameliorated the clinical symptoms of various autoimmune diseases by reducing inflammatory responses, improving Th1/Th2 balance, and inducing regulatory T cells. ASCs are also an ideal vehicle to deliver genes into target tissues for gene therapy because of their unique biological and immunological properties. Using ASCs as a vehicle to insert appropriate therapeutic genes into cells could prove a novel method for immune modulation in autoimmune disease.

Keywords

Mesenchymal Stem Cell Major Histocompatibility Complex Class Dextran Sulfate Sodium Human ASCs Chronic Experimental Autoimmune Encephalomyelitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Laboratory Animal Research CenterSamsung Biomedical Research InstituteSeoulRepublic of Korea
  2. 2.School of MedicineSungkyunkwan UniversitySeoulRepublic of Korea

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