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Cognitive-Enhancing Drugs, Behavioral Training and the Mechanism of Cognitive Enhancement

  • Emma Peng ChienEmail author
Chapter
Part of the Trends in Augmentation of Human Performance book series (TAHP, volume 1)

Abstract

In this chapter, I propose the mechanism of cognitive enhancement based on studies of cognitive-enhancing drugs and behavioral training. I argue that there are mechanistic differences between cognitive-enhancing drugs and behavioral training due to their different enhancing effects. I also suggest possible mechanisms for cognitive-enhancing drugs and behavioral training and for the synergistic effects of their simultaneous application.

Keywords

Cognitive enhancement Mechanism Cognitive-enhancing drugs Behavioral training Synergistic effects 

Notes

Acknowledgement

In preparing the present version of this chapter I benefited from the written comments from Elisabeth Hildt, Sheila Madary, and Andreas G. Franke, and comments and suggestions from the participants in the conference on cognitive enhancement in Mainz, Germany, February 2011. I am grateful to the German Federal Ministry of Education and Research for supporting the trip to the conference and the preparation of this chapter.

References

  1. Berthier ML, Green C, Lara JP, Higueras C, Barbancho MA, Dávila G, Pulvermüller F (2009) Memantine and constraint-induced aphasia therapy in chronic poststroke aphasia. Ann Neurol 65:577–585PubMedCrossRefGoogle Scholar
  2. Cools R, Roberts AC, Robbins TW (2008) Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn Sci 12:31–40PubMedCrossRefGoogle Scholar
  3. Harmer CJ (2008) Serotonin and emotional processing: does it help explain antidepressant drug action? Neuropharmacology 55:1023–1028PubMedCrossRefGoogle Scholar
  4. Husain M, Mehta MA (2011) Cognitive enhancement by drugs in health and disease. Trends Cogn Sci 15:28–36PubMedCrossRefGoogle Scholar
  5. Klingberg T, Fernell E, Olesen PJ, Johnson M, Gustafsson P, Dahlstrom K, Gillberg CG, Forssberg H, Westerberg H (2005) Computerized training of working memory in children with ADHD – a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 44:177–186PubMedCrossRefGoogle Scholar
  6. Knecht S, Breitenstein C, Bushuven S, Wailke S, Kamping S, Flöel A, Zwitserlood P, Ringelstein EB (2004) Levodopa: faster and better word learning in normal humans. Ann Neurol 56:20–26PubMedCrossRefGoogle Scholar
  7. Luciana M, Burgund ED, Berman M, Hanson KL (2001) Effects of tryptophan loading on verbal, spatial and affective working memory functions in healthy adults. J Psychopharmacol 15:219–230PubMedCrossRefGoogle Scholar
  8. Maguire EA, Valentine ER, Wilding JM, Kapur N (2003) Routes to remembering: the brains behind superior memory. Nat Neurosci 6:90–95PubMedCrossRefGoogle Scholar
  9. McNab F, Varrone A, Farde L, Jucaite A, Bystritsky P, Forssberg H, Klingberg T (2009) Changes in cortical dopamine D1 receptor binding associated with cognitive training. Science 323:800–802PubMedCrossRefGoogle Scholar
  10. Olesen PJ, Westerberg H, Klingberg T (2004) Increased prefrontal and parietal activity after training of working memory. Nat Neurosci 7:75–79PubMedCrossRefGoogle Scholar
  11. Robbins TW, Arnsten AFT (2009) The neuropsychopharmacology of fronto-executive function: monoaminergic modulation. Annu Rev Neurosci 32:267–287PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of PhilosophyUniversity of AlbertaEdmontonCanada

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