Lectins of Marine Origin and Their Clinical Applications
During the past several decades, intensive investigations have been conducted to clarify the biochemical and physiological properties of lectins from marine organisms, including cyanobacteria, algae, and invertebrates and fish. These investigations have revealed that lectins are highly diversified in terms of not only structural aspects but also functional aspects, including unique carbohydrate-binding specificities. Lectins are still being intensively investigated to understand their biological roles in cell recognition and biodefense as well as to employ them as valuable tools for studying complex carbohydrates in solution and on cell surfaces. Here, we review the structures and activities of lectins from marine organisms and their applications as carbohydrate recognition molecules and medicinal agents with antitumor and antiviral activities.
KeywordsHuman Immunodeficiency Virus White Spot Syndrome Virus Head Kidney Skin Mucus Galanthus Nivalis Agglutinin
This work was supported by Grants-in-Aid for Scientific Research (23380121) from the Ministry of Education, Science, Sports, and Culture of Japan.
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