Rapamycin: Current and Future Uses
The mTOR inhibitor rapamycin has received growing attention due to its immunosuppresive, antineoplastic and lifespan extending properties. The discovery of the drug and its target has had widespread implications for our understanding of the underlying metabolic processes in the cell. Indeed, rapamycin has opened up a new field of potential pharmacological targets. In the following chapter I will briefly review the molecular target of rapamycin and the current clinical applications for this compound.
KeywordsmTOR Inhibitor Tuberous Sclerosis Complex Peripheral Artery Disease Lichen Planus Rapamycin Treatment
I would like to thank Dr. Vilhelm A. Bohr and Dr. Evandro Fei Fang for invaluable feedback and critically reading the manuscript. This research was supported entirely by the Intramural Research Program of the NIH, National Institute on Aging.
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