Role of Calcium Signaling in Stem and Cancer Cell Proliferation

  • Maria Jimena Amaya
  • Vânia A. M. Goulart
  • Anderson K. Santos
  • Alexandre H. Kihara
  • Silvia Guatimosim
  • Rodrigo R. ResendeEmail author


Calcium (Ca2+) is a ubiquitous second messenger involved in the regulation of many cellular activities. Importantly, both cytosolic and nuclear Ca2+ signals have essential roles in the progression through the cell cycle. Ca2+ signals in the these subcellular compartments are generated through the concerted action of several components of the Ca2+ signaling machinery that reside in the plasma membrane, cytosol, nuclear envelope membrane, or the nucleus. The versatility and specificity of Ca2+ signals is determined by their spatial and temporal patterns, and Ca2+ signals can be regulated independently of cytosolic Ca2+ signals. This review discusses the machinery involved in cytosolic and nuclear Ca2+ signal formation, as well as the different mechanisms through which these Ca2+ signals modulate the process of cell proliferation.


Calcium signaling Stem cells  Cells proliferation  Transcription factors Cancer Nucleoplasm Calcium channels Cell cycle  



We thank the Howard Hughes Medical Institute, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Fundação de Amparo à Pesquisa do Estado de São Paulo, and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Maria Jimena Amaya
    • 1
  • Vânia A. M. Goulart
    • 2
  • Anderson K. Santos
    • 2
  • Alexandre H. Kihara
    • 3
  • Silvia Guatimosim
    • 4
  • Rodrigo R. Resende
    • 2
    Email author
  1. 1.Section of Digestive Diseases, Department of Internal MedicineYale University School of MedicineNew HavenUSA
  2. 2.Cell Signaling and Nanobiotechnology Laboratory, Department of Biochemistry and Immunology, Bloco N4 112 and G3 86Federal University of Minas GeraisBelo HorizonteBrazil
  3. 3.Nucleus of Cognition and Complex Systems, Center for Mathematics, Computation and CognitionUniversidade Federal do ABCSanto AndréBrazil
  4. 4.Cardiomyocyte Intracellular Signaling Laboratory, Department of Physiology and Biophysics, Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteBrazil

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