Abstract
Increases in both the basal cytosolic calcium concentration and cytosolic calcium transients play a major role in cell cycle progression, cell proliferation, and cell division. Calcium influx and calcium release from the endoplasmic reticulum are the major routes involved in the variations in cytosolic calcium concentration, and past studies have clearly shown that calcium influx controls cell growth and proliferation in several cell types. Furthermore, various studies in the past 30 years have demonstrated that cell-specific calcium channel expression levels are determinant in these physiological processes. Cell proliferation is directly linked to cell cycle progression, and it rapidly became evident that calcium channel expression interferes in this physiological process. It is also clear that the relationship between calcium influx and cell proliferation can be uncoupled in transformed and cancer cells, resulting in an external calcium-independent proliferation. Other divalent cations such as iron and zinc involved in cell proliferation permeating some calcium channels may interfere in this cellular process. Finally, we make the assumption that protein expression could be more important rather than channel function to trigger cell proliferation and that additional channel functions may be discovered soon.
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Borowiec, AS., Bidaux, G., Capiod, T. (2013). Are Calcium Channels More Important Than Calcium Influx for Cell Proliferation?. In: Resende, R., Ulrich, H. (eds) Trends in Stem Cell Proliferation and Cancer Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6211-4_4
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