Organisation of the Tetraspanin Web

  • Eric Rubinstein
  • Stéphanie Charrin
  • Michael G. Tomlinson
Part of the Proteins and Cell Regulation book series (PROR, volume 9)


Tetraspanins are currently hypothesized to promote membrane compartmentalization, through their ability to organize a network of molecular interactions termed the tetraspanin web or tetraspanin-enriched microdomains. In this chapter we will describe how the discovery of this unique ability of tetraspanins to interact with one another and with many other surface proteins led to this concept, and will discuss the hierarchical organization of these structures. We will also show how tetraspanins modulate the function of the proteins they associate with, including the regulation of trafficking, ligand binding, signal transduction and enzymatic activities.


Lipid Raft Partner Protein Epidermolysis Bullosa ADAM10 Expression Catch Bond 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Inserm U1004Villejuif CedexFrance
  2. 2.Institut André LwoffUniversity Paris-SudVillejuif CedexFrance
  3. 3.School of Biosciences, College of Life and Environmental SciencesUniversity of BirminghamBirminghamUK

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