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Bioartificial Pancreas: In the Road to Clinical Application

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Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 4))

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Abstract

With the increasing incidence of diabetes, it is urgent to develop a reliable and safe source of insulin production. Conventional transplantation of pancreatic tissue has been demonstrated to be an efficacious method of restoring glycaemic control in type 1 diabetes. However, the lack of donors, the use of immunosuppressants and the early β-cell failure limit the use of this approach. Regenerative medicine has focused on the design and application of bioartificial pancreas to treat this disease. Islet microencapsulation technique enables the transplantation in the absence of immunosuppression by protecting the cells through an immunoisolative membrane. This membrane should be able to protect transplanted allo- and xenogenic cells from the host, while facilitating adequate transport of oxygen, nutrients, and secreted hormones. Although many different materials and immunoisolation devices build-up processes have been studied, their viability in in vivo applications has been compromised. With clarification of all obstacles to the clinical application, new strategies will be developed that would increase the islet performance after transplantation.

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  1. Laboratory of Physiology, Institute of Biomedical Research in Light and Image, Faculty of Medicine of University of Coimbra, Sub-unit 1, 1st floor, Azinhaga de Santa Comba, Celas, 3060-350, Coimbra, Portugal

    Joana Crisóstomo & Raquel Seiça

  2. Research Centre for Chemical Processes Engineering and Forest Products, Chemical Engineering Department, Faculty of Sciences and Technology of University of Coimbra, Polo II – Rua Sílvio Lima, 3030-790, Coimbra, Portugal

    Joana Crisóstomo

  3. Department of Chemical Engineering, University of Coimbra, Polo II, Pinhal de Marrocos, 3030-790, Coimbra, Portugal

    Jorge F. J. Coelho

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  1. , Chemical Engineering, University of Coimbra, Rua Silvio Lima, Coimbra, 3030 790, Portugal

    Jorge Coelho

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Crisóstomo, J., Coelho, J.F.J., Seiça, R. (2013). Bioartificial Pancreas: In the Road to Clinical Application. In: Coelho, J. (eds) Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment. Advances in Predictive, Preventive and Personalised Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6010-3_5

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