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The Importance of Controlled/Living Radical Polymerization Techniques in the Design of Tailor Made Nanoparticles for Drug Delivery Systems

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Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 4))

Abstract

Recent developments in controlled/living radical polymerization methods (CLRP) have created the opportunity to prepare polymeric based systems with site specific functionality that has significantly expanded the range of physical and chemical properties that can be generated in materials prepared by these systems. For example, CLRP prepared block copolymers can self-assemble into nanoparticles that can be used in drug delivery applications. The development of synthetic procedures for preparation of materials targeting new and more efficient drug delivery systems (DDS) is of great interest since ultimately they can mimic most of the properties of biological systems.

This chapter will initially discuss the key aspects of the development of nanotechnology for drug delivery. The cell internalization process will be described and related with the relevant properties required for the “nanocarrier systems”. Afterwards, a summary of the polymeric systems that can be used for DDS will be provided and the importance of CLRP methods in the preparation of polymer-based systems will be discussed. Finally, mechanisms of block copolymers self-assembly will be discussed and supported with some examples of CLRP-based self-assembly systems for drug delivery applications.

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Acknowledgements

The authors gratefully acknowledge FP7-Health-2009-2.4.4-2-Project RdCVF for financial support.

Author information

Authors and Affiliations

  1. Department of Chemical Engineering, University of Coimbra, Polo II, Pinhal de Marrocos, 3030-790, Coimbra, Portugal

    Nuno Rocha, Patrícia Mendonça, Joana R. Góis, Rosemeyre Cordeiro, Ana Fonseca, Paula Ferreira & Jorge Coelho

  2. GE Power and Water, Water and Process Technologies, 4636 Somerton Road, Trevose, PA, 19053, USA

    Tamaz Guliashvili

  3. Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Krzysztof Matyjaszewski

  4. Chemistry Department, University of Coimbra, 3004-535, Coimbra, Portugal

    Arménio Serra

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  1. Nuno Rocha
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  2. Patrícia Mendonça
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  3. Joana R. Góis
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  4. Rosemeyre Cordeiro
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  5. Ana Fonseca
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  6. Paula Ferreira
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  7. Tamaz Guliashvili
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  8. Krzysztof Matyjaszewski
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  9. Arménio Serra
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  10. Jorge Coelho
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Corresponding author

Correspondence to Jorge Coelho .

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Editors and Affiliations

  1. , Chemical Engineering, University of Coimbra, Rua Silvio Lima, Coimbra, 3030 790, Portugal

    Jorge Coelho

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© 2013 Springer Science+Business Media Dordrecht

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Rocha, N. et al. (2013). The Importance of Controlled/Living Radical Polymerization Techniques in the Design of Tailor Made Nanoparticles for Drug Delivery Systems. In: Coelho, J. (eds) Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment. Advances in Predictive, Preventive and Personalised Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6010-3_11

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  • DOI: https://doi.org/10.1007/978-94-007-6010-3_11

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