New Animal Models of Progressive Neurodegeneration: Tools for Developing Predictive Diagnostics and Identifying Presymptomatic Therapeutic Targets

  • Amber L. Marriott
  • Daphne A. Gill
  • Christopher A. Shaw
  • R. Andrew Tasker
Part of the Advances in Predictive, Preventive and Personalised Medicine book series (APPPM, volume 2)


Mental and neurological disorders are increasingly prevalent and constitute a major societal and economic burden worldwide. Many of these diseases and disorders are characterized by progressive deterioration over time that ultimately results in identifiable symptoms that in turn dictate therapy. Disease-specific symptoms, however, often occur late in the degenerative process. A better understanding of the presymptomatic events could allow for the development of new diagnostics and earlier interventions that could slow or stop the disease process. Such studies of progressive neurodegeneration require the use of animal models that are characterized by delayed or slowly developing disease phenotype(s). This brief review describes several examples of such animal models that have recently been developed with relevance to epilepsy, schizophrenia, autism spectrum disorders, amyotrophic lateral sclerosis and Parkinson’s disease.


Autism Spectrum Disorder Autism Spectrum Disorder Temporal Lobe Epilepsy Kainic Acid Domoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Amber Marriott is supported by a Canada Graduate Scholarship awarded through the Natural Sciences and Engineering Research Council of Canada and Daphne Gill is supported by a Post-doctoral fellowship from Innovation PEI. Research funding to the investigators was provided by an NINDS RO1 grant to CAS and an Atlantic Innovation Fund grant to RAT.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Amber L. Marriott
    • 1
  • Daphne A. Gill
    • 1
  • Christopher A. Shaw
    • 2
  • R. Andrew Tasker
    • 1
  1. 1.Department of Biomedical SciencesUniversity of Prince Edward IslandCharlottetownCanada
  2. 2.Departments of Ophthalmology and Visual Sciences and Experimental Medicine and Graduate Program in NeurosciencesUniversity of British ColumbiaVancouverCanada

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