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The Effect of Acupressure on Chemotherapy-induced Nausea

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Evidence-based Non-pharmacological Therapies for Palliative Cancer Care

Part of the book series: Evidence-based Anticancer Complementary and Alternative Medicine ((ACAM,volume 4))

Abstract

This chapter was to review the effect of acupressure on chemotherapy-induced nausea, the incidence of side effects, and discuss the mechanisms of acupressure. A systematic review approach was used, studies included experimental studies, quasi-review approach was used, studies, preclinical studies, clinical trials, systematic reviews, and meta-analyses. Literatures search was conducted in CINAHL, MEDLINE, and PubMed using the key words acupressure, nausea, and cancer. Studies published in peer-reviewed journals between 1 January 2002 and 31 December 2012, which used acupressure as the sole intervention for one group, were included when they were written in English. After applying inclusion and exclusion criteria, twelve studies were eligible for review. Seven randomized controlled trials, two quasi-experimental studies, and three systematic reviews were found. Six of seven clinical trials showed positive results of acupressure on chemotherapy-induced nausea in 1,341 patients with cancer. However, we cannot conclude that acupressure is effective for nausea due to the small number in the samples and the poor quality of the studies. Furthermore, well-designed studies are needed to examine the effect of acupressure on chemotherapy-induced nausea. Three systematic reviews reported that acupressure may decrease chemotherapy-induced nausea in 11 clinical trials. No side effect of acupressure has been reported, whereas the side effects such as redness, swelling, and tenderness of sea bands have been reported. On the other hand, the mechanism of acupressure can be explained by regulation of substance P, serotonin, cholecystokinin, opioids, the autonomic nervous system.

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Authors and Affiliations

  1. Nursing Department, Inha University, 100 Inharo Hightech Center 1504, Namgu Incheon, 402-751, South Korea

    Eun Jin Lee

  2. Emeritus Faculty, University of Kentucky, 413 Cochran Road., Lexington, KY, 40502, USA

    Sherry Warden

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Correspondence to Eun Jin Lee .

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  1. Dept. Clinical Oncology, Queen Elizabeth Hospital, Gascoigne Road 30, Kowloon, Hong Kong SAR

    William C.S. Cho

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Lee, E.J., Warden, S. (2013). The Effect of Acupressure on Chemotherapy-induced Nausea. In: Cho, W. (eds) Evidence-based Non-pharmacological Therapies for Palliative Cancer Care. Evidence-based Anticancer Complementary and Alternative Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5833-9_4

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