Identification of Network Biomarkers for Cancer Diagnosis
Researchers are now routinely identifying cancer biomarkers using proteomic technologies, but the results from independent experiments are highly divergent, and few individual marker candidates have been clinically validated. Cancer is a systems biology disease; hence, the discovery of biomarkers must take account of the complexity and heterogeneity of carcinogenesis. Due to this recognition, there is a growing movement from individual marker discovery to a systems-oriented paradigm. This chapter summarizes recent advances and future perspectives in proteomic study of cancer biomarkers. Of particular interest in this chapter is to describe the emerging network-based biomarker discovery as improved strategies against cancer intervention.
KeywordsCancer Proteomics Biomarkers Network Personalized biomarker
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