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Regenerative Medicine

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Abstract

The transplantation of stem cells from the bone marrow, peripheral blood or cord blood has become a clinical procedure since the 1980s and is now annually performed in ten thousands of patients in the autologous and allogeneic setting world-wide. Refinement of human leukocyte antigen typing as well as recent advances in immunosuppression, anti-infective prophylaxis and therapy as well in supportive care have much improved the outcome of patients with leukemia and lymphoma, aplastic anemia, as well as hereditary diseases of the hematopoietic system. This is still an experimental therapy and patient subgroups that profit most from hematopoietic stem cell transplantation need to be defined. Consideration and classification of co-morbidity indices as well as cytogenetic risk factors are pivotal for making decisions on transplantation modalities. Modern conditioning regimens allow balancing of allo-effects against malignant cells versus normal tissue even in elderly patients. Recent innovations in cellular therapy combine allogeneic stem cell transplantation with genetically engineered or specifically selected T cells and potentially natural killer (NK) cells. Depletion of regulatory T cells and vaccination after allogeneic stem cell transplantation constitute further approaches to improve the long-term outcome of transplanted patients.

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References

  • Aiuti A, Cattaneo F, Galimberti S, Benninghoff U, Cassani B, Callegaro L, Scaramuzza S, Andolfi G, Mirolo M, Brigida I, Tabucchi A, Carlucci F, Eibl M, Aker M, Slavin S, Al Mousa H, Al Ghonaium A, Ferster A, Duppenthaler A, Notarangelo L, Wintergerst U, Buckley RH, Bregni M, Marktel S, Valsecchi MG, Rossi P, Ciceri F, Miniero R, Bordignon C, Roncarolo MG (2009) Gene therapy for immunodeficiency due to adenosine deaminase deficiency. N Engl J Med 360:447–458

    Article  PubMed  CAS  Google Scholar 

  • Amrolia PJ, Almeida A, Davies SC, Roberts IA (2003a) Therapeutic challenges in childhood sickle cell disease. Part 2: a problem-orientated approach. Br J Haematol 120:737–743

    Article  PubMed  Google Scholar 

  • Amrolia PJ, Almeida A, Halsey C, Roberts IA, Davies SC (2003b) Therapeutic challenges in childhood sickle cell disease. Part 1: current and future treatment options. Br J Haematol 120:725–736

    Article  PubMed  Google Scholar 

  • Antoine C, Muller S, Cant A, Cavazzana-Calvo M, Veys P, Vossen J, Fasth A, Heilmann C, Wulffraat N, Seger R, Blanche S, Friedrich W, Abinun M, Davies G, Bredius R, Schulz A, Landais P, Fischer A (2003) Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99. Lancet 361:553–560

    Article  PubMed  Google Scholar 

  • Apperley J, Carreras E, Gluckman E, Gratwohl A, Masszi T (2012) The EBMT-ESH handbook – haematopoietic stem cell transplantation, 6th edn. Forum Service Editore, Genoa

    Google Scholar 

  • Arachchillage DR, Dalley CD, Reilly JT, Wilson G, Collins N, Snowden JA (2010) Long-term dual donor derived haematopoietic reconstitution following double unrelated cord blood transplantation – single unit dominance is not always the case. Br J Haematol 149(2):298–299

    Article  PubMed  Google Scholar 

  • Bacigalupo A, Passweg J (2009) Diagnosis and treatment of acquired aplastic anemia. Hematol Oncol Clin North Am 23:159–170

    Article  PubMed  Google Scholar 

  • Barker JN, Scaradavou A, Stevens CE (2009) Combined effect of total nucleated cell dose and HLA-match on transplant outcome in 1061 cord blood recipients with hematological malignancies. Blood 115(9):1843–1849

    Article  PubMed  Google Scholar 

  • Barnes DW, Loutin JF (1953) Protective effects of implants of splenic tissue. Proc R Soc Med 46:251–252

    PubMed  CAS  Google Scholar 

  • Beelen DW, Gromke T, Trenschel R, Hilgendorf I, Wolff D, Elmaagacli A, Freund M, Casper J (2008) Treosulfan compared to total body irradiation-based preparative regimens before allogeneic stem cell transplantation for acute myeloid leukemia: a retrospective long-term study. ASH Ann Meet Abs 112(11):2149

    Google Scholar 

  • Bhatia M, Walters MC (2008) Hematopoietic cell transplantation for thalassemia and sickle cell disease: past, present and future. Bone Marrow Transplant 41:109–117

    Article  PubMed  CAS  Google Scholar 

  • Bhattacharya D, Czechowicz A, Ooi AG, Rossi DJ, Bryder D, Weissman IL (2009) Niche recycling through division-independent egress of hematopoietic stem cells. J Exp Med 206:2837–2850

    Article  PubMed  CAS  Google Scholar 

  • Bortin MM (1970) A compendium of reported human bone marrow transplants. Transplantation 9:571–587

    Article  PubMed  CAS  Google Scholar 

  • Bradley TR, Metcalf D (1966) The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 44:287–300

    Article  PubMed  CAS  Google Scholar 

  • Breems DA, Lowenberg B (2007) Acute myeloid leukemia and the position of autologous stem cell transplantation. Semin Hematol 44:259–266

    Article  PubMed  Google Scholar 

  • Brown JR (2011) The treatment of relapsed refractory chronic lymphocytic leukemia. Hematol Am Soc Hematol Educ Prog 2011:110–118

    Article  Google Scholar 

  • Casalegno-Garduno R, Schmitt A, Yao J, Wang X, Xu X, Freund M, Schmitt M (2010) Multimer technologies for detection and adoptive transfer of antigen-specific T cells. Cancer Immunol Immunother 59:195–202

    Article  PubMed  CAS  Google Scholar 

  • Casper J, Wolff D, Knauf W, Blau IW, Ruutu T, Volin L, Wandt H, Schäfer-Eckart K, Holowiecki J, Giebel S, Aschan J, Zander AR, Kröger N, Hilgendorf I, Baumgart J, Mylius HA, Pichlmeier U, Freund M (2010) Allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies after dose-escalated treosulfan/fludarabine conditioning. J Clin Oncol 28:3344–3351

    Article  PubMed  CAS  Google Scholar 

  • Chan WW, Wise SC, Kaufman MD, Ahn YM, Ensinger CL, Haack T, Hood MM, Jones J, Lord JW, Lu WP, Miller D, Patt WC, Smith BD, Petillo PA, Rutkoski TJ, Telikepalli H, Vogeti L, Yao T, Chun L, Clark R, Evangelista P, Gavrilescu LC, Lazarides K, Zaleskas VM, Stewart LJ, Van Etten RA, Flynn DL (2011) Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell 19:556–568

    Article  PubMed  CAS  Google Scholar 

  • Colvin GA, Lambert JF, Abedi M, Hsieh CC, Carlson JE, Stewart FM, Quesenberry PJ (2004) Murine marrow cellularity and the concept of stem cell competition: geographic and quantitative determinants in stem cell biology. Leukemia 18:575–583

    Article  PubMed  CAS  Google Scholar 

  • Czechowicz A, Kraft D, Weissman IL, Bhattacharya D (2007) Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science 318:1296–1299

    Article  PubMed  CAS  Google Scholar 

  • Deininger MW (2008) Milestones and monitoring in patients with CML treated with imatinib. Hematol Am Soc Hematol Educ Prog 1:419–426

    Article  Google Scholar 

  • den Haan JM, Meadows LM, Wang W, Pool J, Blokland E, Bishop TL, Reinhardus C, Shabanowitz J, Offringa R, Hunt DF, Engelhard VH, Goulmy E (1998) The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. Science 279:1054–1057

    Article  Google Scholar 

  • Dohner H, Gaidzik VI (2011) Impact of genetic features on treatment decisions in AML. Hematol Am Soc Hematol Educ Prog 2011:36–42

    Article  Google Scholar 

  • Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK, Dombret H, Fenaux P, Grimwade D, Larson RA, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz MA, Sierra J, Tallman MS, Lowenberg B, Bloomfield CD (2010) Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 115:453–474

    Article  PubMed  Google Scholar 

  • Dreger P (2009) Allotransplantation for chronic lymphocytic leukemia. Hematol Am Soc Hematol Educ Prog 2009:602–609

    Article  Google Scholar 

  • Dreger P, Corradini P, Kimby E, Michallet M, Milligan D, Schetelig J, Wiktor-Jedrzejczak W, Niederwieser D, Hallek M, Montserrat E (2007) Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia 21:12–17

    Article  PubMed  CAS  Google Scholar 

  • Ema H, Takano H, Sudo K, Nakauchi H (2000) In vitro self-renewal division of hematopoietic stem cells. J Exp Med 192:1281–1288

    Article  PubMed  CAS  Google Scholar 

  • Ford CE, Hammerton JL, Barnes DW, Loutin JF (1956) Cytological identification of ­radiation-chimaeras. Nature 177:452–454

    Article  PubMed  CAS  Google Scholar 

  • Giannopoulos K, Mertens D, Buhler A, Barth TF, Idler I, Moller P, Krober A, Greiner J, Chocholska S, Dmoszynska A, Rolinski J, Dohner H, Stilgenbauer S, Schmitt M (2009) The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia. Leukemia 23:519–527

    Article  PubMed  CAS  Google Scholar 

  • Ginsburg H, Sachs L (1963) Formation of pure suspension of mast cells in tissue culture by differentiation of lymphoid cells from the mouse thymus. J Natl Cancer Inst 31:1–40

    PubMed  CAS  Google Scholar 

  • Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 18:295–304

    Article  PubMed  CAS  Google Scholar 

  • Gokbuget N, Hoelzer D (2009) Treatment of adult acute lymphoblastic leukemia. Semin Hematol 46:64–75

    Article  PubMed  Google Scholar 

  • Goldstone AH, Richards SM, Lazarus HM, Tallman MS, Buck G, Fielding AK, Burnett AK, Chopra R, Wiernik PH, Foroni L, Paietta E, Litzow MR, Marks DI, Durrant J, McMillan A, Franklin IM, Luger S, Ciobanu N, Rowe JM (2008) In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993). Blood 111:1827–1833

    Article  PubMed  CAS  Google Scholar 

  • Goulmy E, Schipper R, Pool J, Blokland E, Falkenburg JH, Vossen J, Gratwohl A, Vogelsang GB, van Houwelingen HC, Van Rood JJ (1996) Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N Engl J Med 334:281–285

    Article  PubMed  CAS  Google Scholar 

  • Gratwohl A, Stern M, Brand R, Apperley J, Baldomero H, De Witte T, Dini G, Rocha V, Passweg J, Sureda A, Tichelli A, Niederwieser D (2009) Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis. Cancer 115:4715–4726

    Article  PubMed  Google Scholar 

  • Gyan E, Foussard C, Bertrand P, Michenet P, Le Gouill S, Berthou C, Maisonneuve H, Delwail V, Gressin R, Quittet P, Vilque JP, Desablens B, Jaubert J, Ramee JF, Arakelyan N, Thyss A, Molucon-Chabrot C, Delepine R, Milpied N, Colombat P, Deconinck E (2009) High-dose therapy followed by autologous purged stem cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by the GOELAMS with final results after a median follow-up of 9 years. Blood 113:995–1001

    Article  PubMed  CAS  Google Scholar 

  • Hacein-Bey-Abina S, von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint BG, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, MacIntyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M (2003) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302:415–419

    Article  PubMed  CAS  Google Scholar 

  • Harrison DE, Astle CM (1982) Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure. J Exp Med 156:1767–1779

    Article  PubMed  CAS  Google Scholar 

  • Klein J, Sato A (2000a) The HLA system. First of two parts. N Engl J Med 343:702–709

    Article  PubMed  CAS  Google Scholar 

  • Klein J, Sato A (2000b) The HLA system. Second of two parts. N Engl J Med 343:782–786

    Article  PubMed  CAS  Google Scholar 

  • Kodera Y (2008) The Japan marrow donor program, the Japan cord blood bank network and the Asia blood and marrow transplant registry. Bone Marrow Transplant 42(Suppl 1):S6

    Article  PubMed  Google Scholar 

  • Koreth J, Schlenk R, Kopecky KJ, Honda S, Sierra J, Djulbegovic BJ, Wadleigh M, DeAngelo DJ, Stone RM, Sakamaki H, Appelbaum FR, Dohner H, Antin JH, Soiffer RJ, Cutler C (2009) Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA 301:2349–2361

    Article  PubMed  CAS  Google Scholar 

  • Lowenberg B, Ossenkoppele GJ, van Putten W, Schouten HC, Graux C, Ferrant A, Sonneveld P, Maertens J, Jongen-Lavrencic M, Lilienfeld-Toal M, Biemond BJ, Vellenga E, van Marwijk KM, Verdonck LF, Beck J, Dohner H, Gratwohl A, Pabst T, Verhoef G (2009) High-dose daunorubicin in older patients with acute myeloid leukemia. N Engl J Med 361:1235–1248

    Article  PubMed  Google Scholar 

  • Mielke S, McIver ZA, Shenoy A, Fellowes V, Khuu H, Stroncek DF, Leitman SF, Childs R, Battiwalla M, Koklanaris E, Haggerty J, Savani BN, Rezvani K, Barrett AJ (2011) Selectively T cell-depleted allografts from HLA-matched sibling donors followed by Low-dose posttransplantation immunosuppression to improve transplantation outcome in patients with hematologic malignancies. Biol Blood Marrow Transplant 17:1855–1861

    Article  PubMed  CAS  Google Scholar 

  • Mills W, Chopra R, McMillan A, Pearce R, Linch DC, Goldstone AH (1995) BEAM chemotherapy and autologous bone marrow transplantation for patients with relapsed or refractory non-Hodgkin’s lymphoma. J Clin Oncol 13:588–595

    PubMed  CAS  Google Scholar 

  • Moretta A, Pende D, Locatelli F, Moretta L (2009) Activating and inhibitory killer immunoglobulin-like receptors (KIR) in haploidentical haemopoietic stem cell transplantation to cure high-risk leukaemias. Clin Exp Immunol 157:325–331

    Article  PubMed  CAS  Google Scholar 

  • Morrison SJ, Prowse KR, Ho P, Weissman IL (1996) Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5:207–216

    Article  PubMed  CAS  Google Scholar 

  • Mutis T, Gillespie G, Schrama E, Falkenburg JH, Moss P, Goulmy E (1999) Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease. Nat Med 5:839–842

    Article  PubMed  CAS  Google Scholar 

  • Neven B, Leroy S, Decaluwe H, Le Deist F, Picard C, Moshous D, Mahlaoui N, Debre M, Casanova JL, Dal Cortivo L, Madec Y, Hacein-Bey-Abina S, de Saint BG, de Villartay JP, Blanche S, Cavazzana-Calvo M, Fischer A (2009) Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency. Blood 113:4114–4124

    Article  PubMed  CAS  Google Scholar 

  • Nowell PC, Cole LJ, Habermeyer JG, Roan PL (1956) Growth and continued function of rat marrow cells in x-radiated mice. Cancer Res 16:258–261

    PubMed  CAS  Google Scholar 

  • Papayannopoulou T, Scadden DT (2008) Stem-cell ecology and stem cells in motion. Blood 111:3923–3930

    Article  PubMed  CAS  Google Scholar 

  • Piccin A, McCann S, Socie G, Oneto R, Bacigalupo A, Locasciulli A, Marsh J, Schrezenmeier H, Tichelli A, Hand E, Lawler M, Passweg J (2009) Survival of patients with documented autologous recovery after SCT for severe aplastic anemia: a study by the WPSAA of the EBMT. Bone Marrow Transplant 45(6):1008–1013

    Article  PubMed  Google Scholar 

  • Rammensee HG, Falk K, Rotzschke O (1993) Peptides naturally presented by MHC class I molecules. Annu Rev Immunol 11:213–244

    Article  PubMed  CAS  Google Scholar 

  • Rapoport AP, Aqui NA, Stadtmauer EA, Vogl DT, Fang HB, Cai L, Janofsky S, Chew A, Storek J, Akpek G, Badros A, Yanovich S, Tan MT, Veloso E, Pasetti MF, Cross A, Philip S, Murphy H, Bhagat R, Zheng Z, Milliron T, Cotte J, Cannon A, Levine BL, Vonderheide RH, June CH (2011) Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma. Blood 117:788–797

    Article  PubMed  CAS  Google Scholar 

  • Rezvani K (2011) Posttransplantation vaccination: concepts today and on the horizon. Hematol Am Soc Hematol Educ Prog 2011:299–304

    Article  Google Scholar 

  • Ringhoffer M, Harsdorf S, Schmitt M, Wiesneth M, Zenz T, Stilgenbauer S, Greiner J, Dohner K, Marx M, Dohner H, Bunjes D (2007) Reduced-intensity conditioning followed by T-cell depleted allogeneic stem cell transplantation for patients with chronic myeloid leukaemia and minimal residual disease at the time of transplant: high risk of molecular relapse. Br J Haematol 136:127–130

    Article  PubMed  Google Scholar 

  • Saussele S, Lauseker M, Gratwohl A, Beelen DW, Bunjes D, Schwerdtfeger R, Kolb HJ, Ho AD, Falge C, Holler E, Schlimok G, Zander AR, Arnold R, Kanz L, Dengler R, Haferlach C, Schlegelberger B, Pfirrmann M, Muller MC, Schnittger S, Leitner A, Pletsch N, Hochhaus A, Hasford J, Hehlmann R (2009) Allogeneic hematopoietic stem cell transplantation (alloSCT) for chronic myeloid leukemia in the imatinib era; evaluation of its impact within a subgroup of the randomized German CML Study IV. Blood 115(10):1880–1885

    Article  PubMed  Google Scholar 

  • Schmid C, Schleuning M, Schwerdtfeger R, Hertenstein B, Mischak-Weisinger E, Bunjes D, von Harsdorf S, Scheid C, Holtick U, Greinix H, Keil F, Schneider B, Sandherr M, Bug G, Tischer J, Ledderose G, Hallek M, Hiddemann W, Kolb H-J (2006) Longterm survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation. Blood 108:1092–1099

    Article  PubMed  CAS  Google Scholar 

  • Schmid C, Labopin M, Nagler A, Bornhauser M, Finke J, Fassas A, Volin L, Gurman G, Maertens J, Bordigoni P, Holler E, Ehninger G, Polge E, Gorin NC, Kolb HJ, Rocha V (2007) Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party. J Clin Oncol 25:4938–4945

    Article  PubMed  CAS  Google Scholar 

  • Schmitt M, Schmitt A, Rojewski M, Chen J, Götz M, Heyduk M, Giannopoulos K, Ritter G, Gnjatic S, Guillaume P, Ringhoffer M, Schlenk R, Liebisch P, Bunjes D, Shiku H, Döhner H, Greiner J (2008) RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma elicits immunological and clinical responses. Blood 111:1357–1365

    Article  PubMed  CAS  Google Scholar 

  • Schmitt A, Tonn T, Busch D, Grigoleit G, Einsele H, Odenthal M, Germeroth L, Ringhoffer M, Ringhoffer S, Wiesneth M, Detlef M, Mertens T, Rojewski M, Marx M, Harsdorf S, Döhner H, Seifried E, Bunjes D, Schmitt M (2010) Adoptive transfer and selective reconstitution of streptamer-selected CMV-specific CD8+ T cells leads to virus clearance in patients after allo-PBSCT. Transfusion 51:591–599

    Article  PubMed  Google Scholar 

  • Schrezenmeier H, Passweg JR, Marsh JC, Bacigalupo A, Bredeson CN, Bullorsky E, Camitta BM, Champlin RE, Gale RP, Fuhrer M, Klein JP, Locasciulli A, Oneto R, Schattenberg AV, Socie G, Eapen M (2007) Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia. Blood 110:1397–1400

    Article  PubMed  CAS  Google Scholar 

  • Shlomchik WD (2007) Graft-versus-host disease. Nat Rev Immunol 7:340–352

    Article  PubMed  CAS  Google Scholar 

  • Sodani P, Isgro A, Gaziev J, Polchi P, Paciaroni K, Marziali M, Simone MD, Roveda A, Montuoro A, Alfieri C, De Angelis G, Gallucci C, Erer B, Isacchi G, Zinno F, Adorno G, Lanti A, Faulkner L, Testi M, Andreani M, Lucarelli G (2009) Purified T-depleted, CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia. Blood 115(6):1296–1302

    Article  PubMed  Google Scholar 

  • Storb R, Etzioni R, Anasetti C, Appelbaum FR, Buckner CD, Bensinger W, Bryant E, Clift R, Deeg HJ, Doney K (1994) Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia. Blood 84:941–949

    PubMed  CAS  Google Scholar 

  • Surh CD, Sprent J (2005) Regulation of mature T cell homeostasis. Semin Immunol 17:183–190

    Article  PubMed  CAS  Google Scholar 

  • Thomas ED, Lochte HL Jr, Lu WC, Ferrebee JW (1957) Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med 257:491–496

    Article  PubMed  CAS  Google Scholar 

  • Thomas E, Storb R, Clift RA, Fefer A, Johnson FL, Neiman PE, Lerner KG, Glucksberg H, Buckner CD (1975) Bone-marrow transplantation. N Engl J Med 292(832–43):895–902

    Article  PubMed  CAS  Google Scholar 

  • Trowsdale J, Campbell RD (1988) Physical map of the human HLA region. Immunol Today 9:134–137

    Article  Google Scholar 

  • Van Tedeloo VF, Van de Velde V, Van Driesche A et al (2010) Induction of complete and molecular remissions in acute myeloid leukemia by Wilms’ tumor 1 antigen-targeted dendritic cell vaccination. Proc Natl Acad Sci USA 107:13824–13829

    Article  Google Scholar 

  • Vos O, Davids JA, Weyzen WW, van Bekkum DW (1956) Evidence for the cellular hypothesis in radiation protection by bone marrow cells. Acta Physiol Pharmacol Neerl 4:482–486

    PubMed  CAS  Google Scholar 

  • Wang X, Schmitt A, Chen B, Xu X, Mani J, Linnebacher M, Freund M, Schmitt M (2010) Streptamer-based selection of WT1-specific CD8+ T cells for specific donor lymphocyte infusions. Exp Hematol 38:1066–1073

    Article  PubMed  CAS  Google Scholar 

  • Yanada M, Matsuo K, Suzuki T, Naoe T (2006) Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high-risk acute lymphoblastic leukemia: a metaanalysis. Cancer 106:2657–2663

    Article  PubMed  Google Scholar 

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  1. Cellular Immunotherapy, University Clinic Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany

    Michael Schmitt M.D., Ph.D., MHBA

  2. 3rd Medical Department, Hematology, Oncology, Palliative Medicine, Center of Medicine, Rostock University Hospitals, Ernst-Heydemann-Str. 6, D-18055, Rostock, Germany

    Mathias Freund M.D., Ph.D.

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Correspondence to Michael Schmitt M.D., Ph.D., MHBA .

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  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Schmitt, M., Freund, M. (2013). Blood. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5690-8_26

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