Spinal Angiolipoma: Diagnosis and Treatment

  • Miguel Gelabert-González
  • Ramón Serramito-Garcia
  • Eduardo Aran-Echabe
Part of the Tumors of the Central Nervous System book series (TCNS, volume 10)


Spinal angiolipomas are benign uncommon neoplasms originating in mesenchymal tissue, and are composed of mature lipocytes admixed with abnormal blood vessels. Angiolipomas frequently develop in the epidural space of the spine and more rarely in the orbit, the cavernous spaces, thalamus, and account for only 0.04–1.2% of all spinal tumors. These neoplasms can be categorized into two subtypes: non-infiltrating and infiltrating. The former is more common and remains confined to the epidural space whereas the latter invades the contiguous bone and adjacent soft tissues.

Spinal angiolipomas are predominantly located in the mid-thoracic region; hence, most patients present slowly progressive signs of spinal cord compression secondary to epidural mass. Angiolipomas show iso- or hyperintensity on T1-weighted images and hyperintensity on T2-weighted images, and most lesions enhance with gadolinium administration. The treatment for spinal extradural angiolipomas is surgical resection. Complete removal of an epidural non-infiltrating angiolipoma is possible in most cases and the prognosis is excellent and no adjuvant therapy should be administered. For infiltrating neo plasms complete removal may entail complications due to heavy bleeding.


Spinal Canal Epidural Space Spinal Tumor Vertebral Hemangioma Spinal Lipoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Andaluz N, Balko G, Bui H, Zuccarello M (2000) Angiolipomas of the central nervous system. J Neuroncol 49:219–230CrossRefGoogle Scholar
  2. Anson JA, Cybulski GR, Reyes M (1990) Spinal extradural angiolipoma: a report of two cases and review of the literature. Surg Neurol 34:173–178PubMedCrossRefGoogle Scholar
  3. Bailey D, Andrews J, Mazur E, Cleary J (2000) Dorsal thoracic cord compression from a spinal angiolipoma: case report and brief comment. Conn Med 64:267–269PubMedGoogle Scholar
  4. Balado M, Morea R (1928) Extramedular haemangioma producing paraplegia during pregnancy. Arch Argent Neurol 1:345–351Google Scholar
  5. Bardosi S, Schaale TH, Friede RL, Roessmann U (1985) Extradural spinal angiolipoma with secretory activity. An ultrastructural, clinicopathological study. Virchows Arch 406:253–256CrossRefGoogle Scholar
  6. Bender JL, Van Landingham JH, Manno NJ (1974) Epidural lipoma producing spinal cord compression. J Neurosurg 41:100–103PubMedCrossRefGoogle Scholar
  7. Berenbruch K (1890) Association of multiples angiolipomas and angioma of spinal cord, Tubingen: H Laupp, JrGoogle Scholar
  8. Bucy PC, Ritchey H (1947) Klippel-Feil syndrome associated with compression of spinal cord by an extradural hemangiolipoma. J Neurosurg 4:476–481PubMedCrossRefGoogle Scholar
  9. Ehni G, Love JG (1945) Intraspinal lipomas: report of cases, review of the literature, and clinical and pathological study. Arch Neurol Psychiatry 53:1–28CrossRefGoogle Scholar
  10. Fourney DR, Tong KA, Macaulay RJ, Griebel RW (2001) Spinal angiolipoma. Can J Neurol Sci 28:82–88PubMedGoogle Scholar
  11. François P, Zemmoura I, Fouquet AMB, Jan M, Velut S (2010) Lateral sellar angiolipoma: a tumor illustrative of the extradural compartment of the neural axis. J Neurosurg 113:1053–1058PubMedCrossRefGoogle Scholar
  12. Gelabert-González M, García-Allut A (2009) Spinal extradural angiolipoma: report of two cases and review of the literatura. Eur Spine J 18:324–335PubMedCrossRefGoogle Scholar
  13. Gonzalez-Crussi F, Enneking WF, Arean VM (1966) Infiltrating angiolipoma. J Bone Joint Surg Am 48A:1111–1124Google Scholar
  14. Howard WR, Helwig EB (1960) Angiolipoma. Arch Dermatol 82:924–931PubMedCrossRefGoogle Scholar
  15. Klisch J, Spreer J, Bloss HG, Baborie A, Hubbe U (1999) Radiological and histological findings in spinal intramedullary angiolipoma. Neuroradiology 41:584–587PubMedCrossRefGoogle Scholar
  16. Labram EK, El-Shunnar K, Hilton DA, Robertson NJ (1999) Revisited: spinal angiolipoma, three additional cases. Br J Neurosurg 13:25–29PubMedCrossRefGoogle Scholar
  17. Liebscher C (1901) Angiolipoma of the spinal canal with compression of the spinal cord. Pag Med Wochenschr 26:189–191Google Scholar
  18. Lin JJ, Lin F (1974) Two entities in angiolipomas. A study of 459 cases of lipoma with review of literature on infiltrating angiolipoma. Cancer 34:720–727PubMedCrossRefGoogle Scholar
  19. Lipson SJ, Naheedy MH, Kaplan MM, Bienfang DC (1980) Spinal stenosis caused by epidural lipomatosis in Cushing’s syndrome. N Engl J Med 302:336CrossRefGoogle Scholar
  20. Maggi G, Aliberti F, Colucci MR, Petrone G, Dorato P, De Giorgi AM (1996) Spinal intramedullary angiolipoma. Childs Nerv Syst 12:346–349PubMedCrossRefGoogle Scholar
  21. Nishiura I, Kubo Y, Koyama T (1986) Spinal haemangiolipoma: three case reports. Neurochirurgia (Stuttg) 29:63–66Google Scholar
  22. Padovani R, Tognetti F, Speranza S, Pozzati E (1982) Spinal extrathecal hemangiolipomas: report of two cases and review of the literature. Neurosurgery 11:674–677PubMedCrossRefGoogle Scholar
  23. Pagni CA, Canavero S (1992) Spinal epidural angiolipoma: rare or unreported? Neurosurgery 31:758–764PubMedCrossRefGoogle Scholar
  24. Palkovic S, Wassmann H, Bonse R, Kashab M (1988) Angiolipoma of the spinal cord. Magnetic resonance imaging and microsurgical management. Surg Neurol 29:243–245PubMedCrossRefGoogle Scholar
  25. Pearson J, Stellar S, Feigin I (1970) Angiomyolipoma: long term cure following radical approach to malignant-appearing benign intraspinal tumor-report of 3 cases. J Neurosurg 33:466–470PubMedCrossRefGoogle Scholar
  26. Pinto-Rafael JI, Vázquez- Barquero A, Martín-Laez R, García-Valtuille R, Sanz-Alonso F, Figols-Guevara FJ, Pérez-Castro MC, Abascal F, Cerezal L (2002) Spinal angiolipoma. Report of one case. Neurocirugia 13:321–325PubMedGoogle Scholar
  27. Preul MC, Leblanc R, Tampieri D, Robitaille Y, Pokrupa R (1993) Spinal angiolipomas. Report of three cases. J Neurosurg 78:280–286PubMedCrossRefGoogle Scholar
  28. Provenzale JM, McLendon RE (1996) Spinal angiolipomas: MR features. AJNR 17:713–719PubMedGoogle Scholar
  29. Rabin D, Hon BA, Pelz DM, Ang LC, Lee DH, Duggal N (2004) Infiltrating spinal angiolipoma. A case report and review of the literature. J Spinal Disord Tech 17:456–461PubMedCrossRefGoogle Scholar
  30. Rubin G, Gornish M, Sandbank J, Shevach I, Rappaport ZH (1992) Spinal extradural angiolipoma. Case report and review of the literature. Spine 17:719–724PubMedCrossRefGoogle Scholar
  31. Samdani AF, Garonzik IM, Jallo G, Eberhart CG, Zahos P (2004) Spinal angiolipoma: case report and review of the literature. Acta Neurochir (Wien) 146:299–302CrossRefGoogle Scholar
  32. Sciot R, Akerman M, Dal Cin P, De Wever I, Fletcher CD, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Tallini G, Van den Berghe H, Vanni R, Willen H (1997) Cytogenic analysis of subcutaneous angiolipoma: further evidence supporting its difference from ordinary pure lipomas. A report of the CHAMP Study Group. Am J Surg Pathol 21:441–444PubMedCrossRefGoogle Scholar
  33. Turanzas FS, Domínguez J, Eyerbe P, Dhimes P (1994) Infiltrating spinal angiolipoma. Case report. Neurocirugia 5:246–249Google Scholar
  34. Weill A, del Carpio-O’Donovan R, Tampieri D, Melanson D, Ethier R (1991) Spinal angiolipomas: CT and MR aspects. J Comput Assist Tomogr 15:83–85PubMedCrossRefGoogle Scholar
  35. Willis RA (1948) Pathology of tumors. Butterworths, London, p 700Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Miguel Gelabert-González
    • 1
  • Ramón Serramito-Garcia
    • 1
  • Eduardo Aran-Echabe
    • 1
  1. 1.Department of NeurosurgeryUniversity of Santiago de CompostelaSantiago de CompostelaSpain

Personalised recommendations