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Morphine and Metastasis: From Bench to Bedside

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Morphine and Metastasis

Abstract

The possibility that morphine and other opioids may modulate tumour growth and metastasis has been researched for many years. The recent past has seen multiple clinical studies attempting to document whether limiting the perioperative use of morphine is beneficial for cancer surgery patients. Furthermore, a lot of exciting new data has been generated in vitro, but also in preclinical and clinical studies, that indirectly shed light on the effect of opioids on cancer. Future directions in the field may include the role of endogenous morphine in tumour biology, the recent discovery that genetic polymorphisms of the mu opioid receptor are associated with cancer survival, the role of microRNAs in opioid receptor regulation and signalling, and the potential usefulness of peripheral opioid antagonists.

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Abbreviations

MOR:

μ opioid receptor

bFGF:

basic fibroblast growth factor

CABG:

coronary artery bypass grafting

EGFR:

epidermal growth factor receptor

MiRNAs:

micro ribonucleic acids

M3G:

morphine-3-glucuronide

M6G:

morphine-6-glucuronide

MD2:

myeloid differentiation protein-2

NO:

nitric oxide

NOS:

nitric oxide synthase

NOP:

nociceptin receptor

PDGFRβ:

platelet-derived growth factor receptor β

RT-PCR:

reverse transcriptase polymerase chain reaction

TLR4:

toll-like receptor 4

UTR:

untranslated region

VEGFR:

vascular endothelial growth factor receptor

DOR:

δ opioid receptor

KOR:

κ opioid receptor

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Acknowledgements

We are grateful to Peter J. Cabot for critically reading the manuscript.

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  1. School of Pharmacy, Pharmacy Australia Centre of Excellence, University of Queensland, 20 Cornwall Street, Woolloongabba, QLD, 4102, Australia

    Marie-Odile Parat

  2. Outcomes Research Consortium, Cleveland, OH, USA

    Marie-Odile Parat

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    Marie-Odile Parat

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Parat, MO. (2013). Morphine and Metastasis: From Bench to Bedside. In: Parat, MO. (eds) Morphine and Metastasis. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5678-6_1

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