Abstract
Tissue engineering and regenerative medicine hold tremendous promise for repairing diseased or dysfunctional tissues with functional biological replacements. To date, a number of engineered tissues are FDA-approved or are undergoing clinical trials. An important component of engineered tissues is the extracellular matrix (ECM) which provides mechanical and physical stability to the tissue, while also providing instructive signaling cues. In the advent of technological advancements, ECMs can be engineered with greater spatial and mechanical organization to better mimic physiological properties of native ECMs. The ECMs used in the generation of artificial skin and vascular grafts are highlighted as examples of engineered tissues under development and commercialization.
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Huang, N.F. (2013). Tissue Engineering and Regenerative Medicine: Role of Extracellular Matrix Microenvironment. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 9. Stem Cells and Cancer Stem Cells, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5645-8_30
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DOI: https://doi.org/10.1007/978-94-007-5645-8_30
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