Protein Kinase C Signaling in Embryonic Stem Cell Self Renewal and Cardiac Differentiation

  • Deborah Schechtman
  • Denise Aparecida Berti
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 9)


Embryonic stem cells (ESC); proliferate while maintain the ability to differentiate into several cell types (self-renewal). For the efficient use of ESC in cell therapies it is necessary to characterize the specific signaling pathways that lead to ESC differentiation, proliferation and self-renewal. The Protein kinase C (PKC) family of serine/threonine kinases has been identified as key enzymes for the processes of proliferation and differentiation of ESCs to cardiomyocytes however, the exact function of each PKC isoenzyme remains unclear, and this is partially due to the conserved nature of these kinases and the fact that specific modulators have only recently become available. In the present chapter we discuss recent studies describing the function PKC isoenzymes in murine ESC proliferation, self renewal and cardiac-differentiation.


Embryonic Stem Cell Leukemia Inhibitory Factor Murine Embryonic Stem Cell Cardiomyocyte Differentiation Undifferentiated Embryonic Stem Cell 
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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Departmento de Bioquímica, Instituto de QuímicaUniversidade de Sao PauloSao PauloBrazil

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