Solanum nigrum


Selected References

  1. Afolayan AJ, Jimoh FO (2008) Nutritional quality of some wild leafy vegetables in South Africa. Int J Food Sci Nutr 26:1–8Google Scholar
  2. Ahmed AH, Ramzy RM (1997) Laboratory assessment of the molluscicidal and cercaricidal activities of the Egyptian weed, Solanum nigrum L. Ann Trop Med Parasitol 91(8):931–937PubMedCrossRefGoogle Scholar
  3. Ahmed AH, Rifaat MM (2004) Molluscicidal and cercaricidal efficacy of Acanthus mollis and its binary and tertiary combinations with Solanum nigrum and Iris pseudacorus against Biomphalaria alexandrina. J Egypt Soc Parasitol 34(3):1041–1050PubMedGoogle Scholar
  4. Ahmed AH, Rifaat MM (2005) Effects of Solanum nigrum leaves water extract on the penetration and infectivity of Schistosoma mansoni cercariae. J Egypt Soc Parasitol 35(1):33–40PubMedGoogle Scholar
  5. Ahmed AH, Kamal IH, Ramzy RM (2001) Studies on the molluscicidal and larvicidal properties of Solanum nigrum L. leaves ethanol extract. J Egypt Soc Parasitol 31(3):843–852PubMedGoogle Scholar
  6. Akhtar MS, Munir M (1989) Evaluation of the gastric antiulcerogenic effects of Solanum nigrum, Brassica oleracea and Ocimum basilicum in rats. J Ethnopharmacol 27(1–2):163–176PubMedCrossRefGoogle Scholar
  7. Al Chami L, Méndez R, Chataing B, O’Callaghan J, Usubillaga A, LaCruz L (2003) Toxicological effects of alpha-solamargine in experimental animals. Phytother Res 17(3):254–258PubMedCrossRefGoogle Scholar
  8. Al-Daihan S (2010) Effect of plant molluscicides on selected enzymes related to energy metabolism in Biomphalaria arabica snails molluscan hosts to Schistosoma mansoni in Saudi Arabia. J Egypt Soc Parasitol 40(1):187–195PubMedGoogle Scholar
  9. Al-Daihan S, Kaggwa JS, El-Ansary AK (2010) The effect of a sublethal concentration of Solanum nigrum on some antioxidants in Biomphalaria arabica. J Egypt Soc Parasitol 40(1):205–214PubMedGoogle Scholar
  10. Al-Qirim T, Zaidi SM, Shahwan M, Shattat G, Banu N (2008) Effect of Solanum nigrum on immobilization stress induced antioxidant defense changes in rat. Res J Biol Sci 3(12):1426–1429Google Scholar
  11. An HJ, Kwon KB, Cho HI, Seo EA, Ryu DG, Hwang WJ, Yoo SJ, Kim YK, Hong SH, Kim HM (2005) Solanum nigrum produces nitric oxide via nuclear factor-kappaB activation in mouse peritoneal macrophages. Eur J Cancer Prev 14(4):345–350PubMedCrossRefGoogle Scholar
  12. Arulmozhi V, Krishnaveni M, Karthishwaran K, Dhamodharan G, Mirunalini S (2010) Antioxidant and antihyperlipidemic effect of Solanum nigrum fruit extract on the experimental model against chronic ethanol toxicity. Pharmacogn Mag 6(21):42–50PubMedCrossRefGoogle Scholar
  13. Bean AR (2006) Solanum species of Eastern Australia. Queensland Herbarium, Toowong
  14. Briggs LH, Cambie RC, Hoare JL (1961) Solanum alkaloids. Part XV. The constituents of some Solanum species and a reassessment of solasodamine and solauricine. J Chem Soc 1961:4645–4649CrossRefGoogle Scholar
  15. Bromilow C (1995) Problem plants of south Africa. Briza Publications, Pretoria, 315 ppGoogle Scholar
  16. Burkill IH (1966) A dictionary of the economic products of the Malay Peninsula, Revised reprint, 2 vols. Ministry of agriculture and co-operatives, Kuala Lumpur, pp 1–1240, 1241–2444, vol 1 (A–H), vol 2 (I–Z).Google Scholar
  17. Carle R (1981) Investigations on the content of steroidal alkaloids and sapogenins within Solanum sect. Solanum ( = sect. Morella) (Solanaceae). Plant Syst Evol 138(1–2):61–71CrossRefGoogle Scholar
  18. Chen R, Feng L, Li HD, Zhang H, Yang F (2009) Two novel oligosaccharides from Solanum nigrum. Carbohydr Res 344(13):1775–1777PubMedCrossRefGoogle Scholar
  19. Chen Y, Li S, Sun F, Han H, Zhang X, Fan Y, Tai G, Zhou Y (2010) In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants. Pharm Biol 48(9):1018–1024PubMedCrossRefGoogle Scholar
  20. Chinthana P, Ananthi T (2012) Protective Effect of Solanum nigrum and Solanum trilobatum aqueous leaf extract on lead induced neurotoxicity in albino mice. J Chem Pharm Res 4(1):72–74Google Scholar
  21. Chopra RN, Nayar SL, Chopra IC (1986) Glossary of Indian medicinal plants (Including the supplement). Council Scientific Industrial Research, New Delhi, 330 ppGoogle Scholar
  22. Chweya JA (1997) Genetic enhancement of indigenous vegetables in Kenya. In Guarino L (ed) Traditional African vegetables. Promoting the conservation and use of underutilized and neglected crops. 16. In: Proceedings of the IPGRI international workshop on genetic resources of traditional vegetables in Africa: conservation and use, 29–31 Aug 1995, ICRAF-HQ, Nairobi, Kenya. Institute of Plant Genetics and Crop Plant Research, Gatersleben/International Plant Genetic Resources Institute, Rome, Italy, pp 90–99Google Scholar
  23. Conn BJ (2007) Solanum nigrum L. New South Wales flora online. PlantNET – The plant information network system of Botanic Gardens Trust. Royal Botanic Gardens and Domain Trust, Sydney
  24. de Melo AC, Perec CJ, Rubio MC (1978) Acetylcholine-like activity in the fruit of the black nightshade (Solanaceae). Acta Physiol Lat Am 28(4–5):19–26PubMedGoogle Scholar
  25. Dhellot JR, Matouba E, Maloumbi MG, Nzikou JM, Dzondo MG, Linder M, Parmentier M, Desobry S (2006) Extraction and nutritional properties of Solanum nigrum L seed oil. Afr J Biotechnol 5(10):987–991Google Scholar
  26. Ding X, Zhu FS, Li M, Gao SG (2012) Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. J Ethnopharmacol 139(2):599–604PubMedCrossRefGoogle Scholar
  27. Dokosi OB (1998) Herbs of Ghana. Ghana University Press, Accra, 746 ppGoogle Scholar
  28. Edmonds JM, Chweya JA (1997) Black nightshades, Solanum nigrum L., and related species, Promoting the conservation and Use of underutilized and neglected crops 15. IPGRI/IPK, Rome/Gatersleben, 113 ppGoogle Scholar
  29. Elango V, Oliver C, Raghu PS (2012) Anti-inflammatory activity of the flower extracts of Solanum nigrum in rats. Hygeia J D Med 4(1):59–62Google Scholar
  30. El-Sherbini GT, Zayed RA, El-Sherbini ET (2009) Molluscicidal activity of some Solanum species extracts against the snail Biomphalaria alexandrina. J Parasitol Res 2009 (2009), Article ID 474360Google Scholar
  31. Eltayeb EA, Al-Ansari AS, Roddick JG (1997) Changes in the steroidal alkaloid solasodine during development of Solanum nigrum and Solanum incanum. Phytochemistry 46(3):489–494CrossRefGoogle Scholar
  32. FAO (1988) Traditional food plants. A resource book for promoting the exploitation and consumption of food plants in arid, semi-arid and sub-humid lands of Eastern Africa, FAO food and nutrition paper 42. FAO, Rome, pp 458–466Google Scholar
  33. Fortuin FTJM, Omta SWP (1980) Growth analysis and shade experiment with Solanum nigrum L., the black nightshade, a leaf and a fruit vegetable in West Java. Neth J Agric Sci 28(4):199–210Google Scholar
  34. Foundation for Revitalisation of Local Health Traditions (2008) FRLHT Database. htttp://
  35. Fox FW, Norwood Young ME (1982) Food from the veld: edible wild plants of Southern Africa. Delta Books, Johannesburg, 399 ppGoogle Scholar
  36. Glew RS, Amoako-Atta B, Ankar-Brewoo G, Presley J, Chuang LT, Millson M, Smith BR, Glew RH (2009) Non-cultivated plant foods in West Africa: nutritional analysis of the leaves of three indigenous leafy vegetables in Ghana. Food 3(1):39–42Google Scholar
  37. Gogoi P, Islam M (2012) Ethnomedicinal study of Solanum nigrum L and S. myriacanthus Dunal used by tribals and non-tribals from districts of Upper Assam, India. Asian J Exp Biol Sci 3(1):73–81Google Scholar
  38. Grieve M (1971) A modern herbal. Penguin, 2 vols. Dover publications, New York, 919 ppGoogle Scholar
  39. Hammami H, Ayadi A (2008) Molluscicidal and antiparasitic activity of Solanum nigrum villosum against Galba truncatula infected or uninfected with Fasciola hepatica. J Helminthol 82(3):235–239PubMedCrossRefGoogle Scholar
  40. Hammami H, Mezghani-Jarraya R, Damak M, Ayadi A (2011) Molluscicidal activity of various solvent extracts from Solanum nigrum var. villosum L. aerial parts against Galba truncatula. Parasite 18(1):63–70PubMedCrossRefGoogle Scholar
  41. Hebbar SS, Harsha VH, Shripathi V, Hegde GR (2004) Ethnomedicine of Dharwad district in Karnataka, India – plants used in oral health care. J Ethnopharmacol 94(2–3):261–266PubMedCrossRefGoogle Scholar
  42. Henderson RJF (1974) Solanum nigrum L. (Solanaceae) and related species in Australia. Contrib Qld Herb 16:1–78Google Scholar
  43. Heo KS, Lim KT (2004) Antioxidative effects of glycoprotein isolated from Solanum nigrum L. J Med Food 7(3):349–357PubMedGoogle Scholar
  44. Heo KS, Lim KT (2005) Glycoprotein isolated from Solanum nigrum L. modulates the apoptotic-related signals in 12-O-tetradecanoylphorbol 13-acetate-stimulated MCF-7 cells. J Med Food 8(1):69–77PubMedCrossRefGoogle Scholar
  45. Heo KS, Lee SJ, Ko JH, Lim K, Lim KT (2004a) Glycoprotein isolated from Solanum nigrum L. inhibits the DNA-binding activities of NF-kappaB and AP-1, and increases the production of nitric oxide in TPA-stimulated MCF-7 cells. Toxicol In Vitro 18(6):755–763PubMedCrossRefGoogle Scholar
  46. Heo KS, Lee SJ, Lim KT (2004b) Cytotoxic effect of glycoprotein isolated from Solanum nigrum L. through the inhibition of hydroxyl radical-induced DNA-binding activities of NF-kappa B in HT-29 cells. Environ Toxicol Pharmacol 17(1):45–54PubMedCrossRefGoogle Scholar
  47. Holm LG, Plucknett DL, Pancho JV, Herberger JP (1977) The world’s worst weeds: distribution and biology. East–west Center, University Press of Hawaii, Honolulu, 609 ppGoogle Scholar
  48. Hsieh CC, Fang HL, Lina WC (2008) Inhibitory effect of Solanum nigrum on thioacetamide-induced liver fibrosis in mice. J Ethnopharmacol 119(1):117–121PubMedCrossRefGoogle Scholar
  49. Hsu JD, Kao SH, Tu CC, Li YJ, Wang CJ (2009) Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes. J Agric Food Chem 57(18):8628–8634PubMedCrossRefGoogle Scholar
  50. Hu SY (2005) Food plants of China. The Chinese University Press, Hong Kong, 844 ppGoogle Scholar
  51. Hu K, Kobayashi H, Dong A, Jing Y, Iwasaki S, Yao X (1999) Antineoplastic agents III: steroidal glycosides from Solanum nigrum. Planta Med 65:35–38PubMedCrossRefGoogle Scholar
  52. Huang HC, Syu KY, Lin JK (2010) Chemical composition of Solanum nigrum Linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cells. J Agric Food Chem 58(15):8699–8708PubMedCrossRefGoogle Scholar
  53. Ikeda T, Ando J, Miyazono Zhu XH, Tsumagari H, Nohara T, Yokomizo K, Uyeda M (2000a) Anti-herpes virus activity of Solanum steroidal glycosides. Biol Pharm Bull 23(3):363–364PubMedCrossRefGoogle Scholar
  54. Ikeda T, Tsumagari H, Nohara T (2000b) Steroidal oligoglycosides from Solanum nigrum L. Chem Pharm Bull 48(7):1062–1064PubMedCrossRefGoogle Scholar
  55. Itoh T, Tamura T, Matsumoto T (1977a) 4-desmethylsterols in the seeds of Solanaceae. Steroids 30(3):425–433PubMedCrossRefGoogle Scholar
  56. Itoh T, Tamura T, Matsumoto T (1977b) Triterpene alcohols in the seeds of Solanaceae. Phytochemistry 16(11):1973–1976CrossRefGoogle Scholar
  57. Itoh T, Ishii T, Tamura T, Matsumoto T (1978) Four new and other 4α-methylsterols in the seeds of Solanaceae. Phytochemistry 17(5):971–977CrossRefGoogle Scholar
  58. Jain R, Sharma A, Gupta S, Sarethy IP, Gabrani R (2011) Solanum nigrum: current perspectives on therapeutic properties. Altern Med Rev 16(1):78–85PubMedGoogle Scholar
  59. Jainu M, Devi CSS (2004) Antioxidant effect of methanolic extract of Solanum nigrum berries on aspirin induced gastric mucosal injury. Indian J Clin Biochem 19(1):57–61PubMedCrossRefGoogle Scholar
  60. Jainu M, Devi CSS (2006) Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation. J Ethnopharmacol 104(1–2):156–163PubMedCrossRefGoogle Scholar
  61. Jami SK, Swathi Anuradha T, Guruprasad L, Kirti PB (2007) Molecular, biochemical and structural characterization of osmotin-like protein from black nightshade (Solanum nigrum). J Plant Physiol 164(3):238–252PubMedCrossRefGoogle Scholar
  62. Jansen PCM (2008) Solanum nigrum L. [Internet] Record from Protabase. In: Schmelzer GH,Gurib-Fakim A (eds) PROTA (Plant Resources of Tropical Africa / Ressources végétales de l’Afrique tropicale), Wageningen.
  63. Javed T, Ashfaq UA, Riaz S, Rehman S, Riazuddin S (2011) In-vitro antiviral activity of Solanum nigrum against Hepatitis C Virus. Virol J 8:26PubMedCrossRefGoogle Scholar
  64. Jeong JB, Jeong HJ, Park JH, Lee SH, Lee JR, Lee HK, Chung GY, Choi JD, de Lumen BO (2007) Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb). J Agric Food Chem 55(26):10707–10713PubMedCrossRefGoogle Scholar
  65. Jeong JB, De Lumen BO, Jeong HJ (2010) Lunasin peptide purified from Solanum nigrum L. protects DNA from oxidative damage by suppressing the generation of hydroxyl radical via blocking fenton reaction. Cancer Lett 293(1):58–64PubMedCrossRefGoogle Scholar
  66. Ji YB, Gao SY, Ji CF, Zou X (2008) Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein. J Ethnopharmacol 115(2):194–202PubMedCrossRefGoogle Scholar
  67. Jimoh FO, Adedapo AA, Afolayan AJ (2010) Comparison of the nutritional value and biological activities of the acetone, methanol and water extracts of the leaves of Solanum nigrum and Leonotis leonorus. Food Chem Toxicol 48(3):964–971PubMedCrossRefGoogle Scholar
  68. Jisha S, Sreeja S, Manjula S (2011) In vitro & in vivo estrogenic activity of glycoside fractions of Solanum nigrum fruit. Indian J Med Res 134(3):369–374PubMedGoogle Scholar
  69. Kang H, Jeong HD, Choi HY (2011) The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-α in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2. Am J Chin Med 39(6):1261–1273PubMedCrossRefGoogle Scholar
  70. Khanna P, Rathore AK (1977) Diosgenin and solasodine from Solanum nigrum L. complex. Indian J Exp Biol 15:808–809Google Scholar
  71. Kokwaro JO (2009) Medicinal plants of east Africa, 3rd edn. University of Nairobi Press, Nairobi, 534 ppGoogle Scholar
  72. Kumar PV, Shashidhara S, Kumar MM, Sridhara BY (2001) Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro. Fitoterapia 72(5):481–486PubMedCrossRefGoogle Scholar
  73. Kuo KW, Hsu SH, Li YP, Lin WL, Liu LF, Chang LC, Lin CC, Lin CN, Sheu HM (2000) Anticancer activity evaluation of the solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells. Biochem Pharmacol 60(12):1865–1873PubMedCrossRefGoogle Scholar
  74. Kwon YI, Apostolidis E, Shetty K (2008) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresour Technol 99(8):2981–2988PubMedCrossRefGoogle Scholar
  75. Lee SJ, Lim KT (2006a) Apoptosis induced by glycoprotein (150-kDa) isolated from Solanum nigrum L. is not related to intracellular reactive oxygen species (ROS) in HCT-116 cells. Cancer Chemother Pharmacol 57(4):507–516PubMedCrossRefGoogle Scholar
  76. Lee SJ, Lim KT (2006b) 150 kDa glycoprotein isolated from Solanum nigrum Linne stimulates caspase-3 activation and reduces inducible nitric oxide production in HCT-116 cells. Toxicol In Vitro 20(7):1088–1097PubMedCrossRefGoogle Scholar
  77. Lee SJ, Lim KT (2008) Cell death signal by glycine- and proline-rich plant glycoprotein is transferred from cytochrome c and nuclear factor kappa B to caspase 3 in Hep3B cells. J Nutr Biochem 19(3):166–174PubMedCrossRefGoogle Scholar
  78. Lee SJ, Oh PS, Ko JH, Lim K, Lim KT (2004) A 150-kDa glycoprotein isolated from Solanum nigrum L. has cytotoxic and apoptotic effects by inhibiting the effects of protein kinase C alpha, nuclear factor-kappa B and inducible nitric oxide in HCT-116 cells. Cancer Chemother Pharmacol 54(6):562–572PubMedCrossRefGoogle Scholar
  79. Lee SJ, Ko JH, Lim KT (2005a) Glycine- and proline-rich glycoprotein isolated from Solanum nigrum Linne activates caspase-3 through cytochrome c in HT-29 cells. Oncol Rep 14(3):789–796PubMedGoogle Scholar
  80. Lee SJ, Ko JH, Lim K, Lim KT (2005b) 150 kDa glycoprotein isolated from Solanum nigrum Linneaus enhances activities of detoxicant enzymes and lowers plasmic cholesterol in mouse. Pharmacol Res 51(5):399–408PubMedCrossRefGoogle Scholar
  81. Li J, Li QW, Feng T, Zhang T, Li K, Zhao R, Han Z, Gao D (2007) Antitumor activity of crude polysaccharides isolated from Solanum nigrum Linne on U14 cervical carcinoma bearing mice. Phytother Res 21(9):832–840PubMedCrossRefGoogle Scholar
  82. Li J, Li QW, Feng T, Li K (2008a) Aqueous extract of Solanum nigrum inhibit growth of cervical carcinoma (U14) via modulating immune response of tumor bearing mice and inducing apoptosis of tumor cells. Fitoterapia 79(7–8):548–556PubMedCrossRefGoogle Scholar
  83. Li J, Li QW, Gao DW, Han ZS, Li K (2008b) Antitumor effects of total alkaloids isolated from Solanum nigrum in vitro and in vivo. Pharmazie 63(7):534–538PubMedGoogle Scholar
  84. Li J, Li QW, Gao DW, Han ZS, Lu WZ (2009) Antitumor and immunomodulating effects of polysaccharides isolated from Solanum nigrum Linne. Phytother Res 23(11):1524–1530PubMedCrossRefGoogle Scholar
  85. Li J, Li QW, Peng Y, Zhao R, Han Z, Gao D (2010) Protective effects of fraction 1a of polysaccharides isolated from Solanum nigrum Linne on thymus in tumor-bearing mice. J Ethnopharmacol 129(3):350–356PubMedCrossRefGoogle Scholar
  86. Liang CH, Liu LF, Shiu LY, Huang YS, Chang LC, Kuo KW (2004) Action of solamargine on TNFs and cisplatin-resistant human lung cancer cells. Biochem Biophys Res Commun 322(3):751–758PubMedCrossRefGoogle Scholar
  87. Liang CH, Shiu LY, Chang LC, Sheu HM, Kuo KW (2007) Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Mol Nutr Food Res 51:999–1005PubMedCrossRefGoogle Scholar
  88. Liang CH, Shiu LY, Chang LC, Sheu HM, Tsai EM, Kuo KW (2008) Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin. Chem Res Toxicol 21(2):393–399PubMedCrossRefGoogle Scholar
  89. Lim KT (2005) Glycoprotein isolated from Solanum nigrum L. kills HT-29 cells through apoptosis. J Med Food 8(2):215–226PubMedCrossRefGoogle Scholar
  90. Lin HM, Tseng HC, Wang CJ, Chyau CC, Liao KK, Peng PL, Chou FP (2007) Induction of autophagy and apoptosis by the extract of Solanum nigrum Linn in HepG2 cells. J Agric Food Chem 55(9):3620–3628PubMedCrossRefGoogle Scholar
  91. Lin HM, Tseng HC, Wang CJ, Lin JJ, Lo CW, Chou FP (2008) Hepatoprotective effects of Solanum nigrum Linn extract against CCl4-iduced oxidative damage in rats. Chem Biol Interact 171(3):283–293PubMedCrossRefGoogle Scholar
  92. Lin TC, Fan MC, Wang SY, Huang JW (2011) Identification of the Solanum nigrum extract component involved in controlling cabbage black leaf spot disease. J Agric Food Chem 59(5):1667–1672PubMedCrossRefGoogle Scholar
  93. Liu LF, Liang CH, Shiu LY, Lin WL, Lin CC, Kuo KW (2004) Action of solamargine on human lung cancer cells–enhancement of the susceptibility of cancer cells to TNFs. FEBS Lett 577(1–2):67–74PubMedCrossRefGoogle Scholar
  94. Lomash V, Parihar SK, Jain NK, Katiyar AK (2010) Effect of Solanum nigrum and Ricinus communis extracts on histamine and carrageenan-induced inflammation in the chicken skin. Cell Mol Biol (Noisy-le-Grand) 56(Suppl):OL1239–OL1251Google Scholar
  95. Milner SE, Brunton NP, Jones PW, O’ Brien NM, Collins SG, Maguire AR (2011) Bioactivities of glycoalkaloids and their aglycones from Solanum species. J Agric Food Chem 59(8):3454–3484PubMedCrossRefGoogle Scholar
  96. Mohamed Saleem TS, Chetty CM, Ramkanth S, Alagusundaram M, Gnanaprakash K, Thiruvengada Rajan VS, Angalaparameswari S (2009) Solanum nigrum Linn.- a review. Pharmacogn Rev 3:342–345Google Scholar
  97. Mohy-Ud-Din A, Khan Z-U-D, Ahmad M, Kashmiri MA, Yasmin S, Mazhar H (2009) Chemotaxonomic significance of flavonoids in the Solanum nigrum complex. J Chil Chem Soc 54(4):486–490Google Scholar
  98. Mohy-Ud-Din A, Khan Z-U-D, Ahmad M, Kashmiri MA (2010) Chemotaxonomic value of alkaloids in Solanum nigrum complex. Pak J Bot 42(1):653–660Google Scholar
  99. Nawab A, Thakur VS, Yunus M, Ali Mahdi A, Gupta S (2012) Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum. Int J Mol Med 29(2):277–284PubMedGoogle Scholar
  100. Nawwar MAM, El-Mousallamya AMD, Barakat HH (1989) Quercetin 3-glycosides from the leaves of Solanum nigrum. Phytochemistry 28(6):1755–1757CrossRefGoogle Scholar
  101. Nirmal SA, Patel AP, Bhawar SB, Pattan SR (2012) Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma. J Ethnopharmacol 142(1):91–97PubMedCrossRefGoogle Scholar
  102. Nzikou JM, Mvoula-Tsieri M, Matos L, Matouba E, Ngakegni-Limbili AC, Linder M, Desobry S (2007) Solanum nigrum L. seeds as an alternative source of edible lipids and nutriment in Congo Brazzaville. J Appl Sci 7:1107–1115CrossRefGoogle Scholar
  103. Ochse JJ, van den Brink RC B (1980) Vegetables of the Dutch Indies, 3rd edn. Ascher & Co, Amsterdam, 1016 ppGoogle Scholar
  104. Ohno M, Murakami K, El-Aasr M, Zhou JR, Yokomizo K, Ono M, Nohara T (2012) New spirostanol glycosides from Solanum nigrum and S. jasminoides. J Nat Med 66(4):658–663PubMedCrossRefGoogle Scholar
  105. Pacific Island Ecosystems at Risk (PIER) (2006) Solanum nigrum Cav., Solanaceae.
  106. Patel S, Gheewala N, Suthar A, Shah A (2009) In-vitro cytotoxicity activity of Solanum nigrum extract against hela cell line and vero cell line. Int J Pharm Pharm Sci 1(1):38–46Google Scholar
  107. PBI Solanum Project (2011) Solanaceae Source. May 2011.
  108. Perez RM, Perez JA, Garcia LM, Sossa H (1998) Neuropharmacological activity of Solanum nigrum fruit. J Ethnopharmacol 62(1):43–48PubMedCrossRefGoogle Scholar
  109. Poczai P, Hyvönen J (2011) On the origin of Solanum nigrum: can networks help? Mol Biol Rep 38(2):1171–1185PubMedCrossRefGoogle Scholar
  110. Porcher MH et al (1995–2020) Searchable World Wide Web multilingual multiscript plant name database. Published by The University of Melbourne, Australia.
  111. Raghavendra K, Singh SP, Subbarao SK, Dash AP (2009) Laboratory studies on mosquito larvicidal efficacy of aqueous & hexane extracts of dried fruit of Solanum nigrum Linn. Indian J Med Res 130(1):74–77PubMedGoogle Scholar
  112. Raju K, Anbuganapathi G, Gokulakrishnan V, Rajkapoor B, Jayakar B, Manian S (2003) Effect of dried fruits of Solanum nigrum Linn against CCl4-induced hepatic damage in rats. Biol Pharm Bull 26(11):1618–1619PubMedCrossRefGoogle Scholar
  113. Rao GR (1978) Role of fruit pigments in understanding the inter-relationships and mechanism of evolution of higher chromosomal forms of the species of the Solanum nigrum L. complex. Acta Bot Indic 6(Suppl):41–47Google Scholar
  114. Ravi V, Saleem TSM, Maiti PP, Gauthaman K, Ramamurthy J (2009a) Phytochemical and pharmacological evaluation of Solanum nigrum Linn. Afri J Pharm Pharmacol 3(9):454–457Google Scholar
  115. Ravi V, Saleem TSM, Patel SS, Raamamurthy J, Gauthaman K (2009b) Anti-inflammatory effect of methanolic extract of Solanum nigrum Linn berries. Int J Appl Res Nat Prod 2(2):33–36Google Scholar
  116. Rawani A, Ghosh A, Chandra G (2010) Mosquito larvicidal activities of Solanum nigrum L. leaf extract against Culex quinquefasciatus Say. Parasitol Res 107(5):1235–1240PubMedCrossRefGoogle Scholar
  117. Saijo R, Murakami K, Nohara T, Tomimatsu T, Sato A, Matsuoka K (1982) Studies on the constituents of Solanum plants. II. On the constituents of the immature berries of Solanum nigrum L. Yakugaku Zasshi 102(3):300–305, In JapanesePubMedGoogle Scholar
  118. Sánchez-Mata MC, Yokoyama WE, Hong YJ, Prohens J (2010) Alpha-solasonine and alpha-solamargine contents of gboma (Solanum macrocarpon L.) and scarlet (Solanum aethiopicum L.) eggplants. J Agric Food Chem 58(9):5502–5508PubMedCrossRefGoogle Scholar
  119. Savchenko T, Whiting P, Germade A, Dinan L (2000) Ecdysteroid agonist and antagonist activities in species of the Solanaceae. Biochem Syst Ecol 28(5):403–419PubMedCrossRefGoogle Scholar
  120. Schilling EE, Ma QS, Anderson RN (1992) Common names and species identification in blacknightshades, Solanum sect. Solanum (Solanaceae). Econ Bot 46:223–225CrossRefGoogle Scholar
  121. Sharma SC, Chand R, Sati OP, Sharma AK (1983) Oligofurostanosides from Solanum nigrum. Phytochemistry 22(5):1241–1244CrossRefGoogle Scholar
  122. Shiu LY, Chang LC, Liang CH, Huang YS, Sheu HM, Kuo KW (2007) Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin. Food Chem Toxicol 45(11):2155–2164PubMedCrossRefGoogle Scholar
  123. Shiu LY, Liang CH, Chang LC, Sheu HM, Tsai EM, Kuo KW (2009) Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu. Biosci Rep 29(1):35–45PubMedCrossRefGoogle Scholar
  124. Shokrzadeh M, Azadbakht M, Ahangar N, Hashemi A, Saeedi Saravi SS (2010) Cytotoxicity of hydro-alcoholic extracts of Cucurbita pepo and Solanum nigrum on HepG2 and CT26 cancer cell lines. Pharmacogn Mag 6(23):176–179PubMedCrossRefGoogle Scholar
  125. Siemonsma JS, Jansen PCM (1994) Solanum americanum Miller. In: Siemonsma JS, Piluek K (eds) Plant resources of South-East Asia, no. 8. Vegetables. Prosea Foundation, Bogor, pp 252–255Google Scholar
  126. Singh SP, Raghavendra K, Singh RK, Subbarao SK (2001) Studies on larvicidal properties of leaf extract of Solanum nigrum Linn. (family Solanaceae). Curr Sci 81(12):1529–1530Google Scholar
  127. Son YO, Kim J, Lim JC, Chung Y, Chung GH, Lee JC (2003) Ripe fruit of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 cells. Food Chem Toxicol 41(10):1421–1428PubMedCrossRefGoogle Scholar
  128. Stuart GU (2012) Philippine alternative medicine. Manual of some Philippine medicinal plants.
  129. Subash KR, Ramesh KS, Charian BV, Britto F, Jagan Rao N, Vijaykumar S (2011) Study of hepatoprotective activity of Solanum nigrum and Cichorium intybus. Int J Pharmacol 7(4):504–509CrossRefGoogle Scholar
  130. Sultana S, Perwaiz S, Igbal M, Athar M (1995) Crude extract of hepatoprotective plants Solanum nigrum and Cichorium intybus inhibit free radical mediated damage in free radical-mediated DNA damage. J Ethnopharmacol 45(3):189–192PubMedCrossRefGoogle Scholar
  131. Sun L, Zhao Y, Li X, Yuan H, Cheng A, Lou H (2010) A lysosomal-mitochondrial death pathway is induced by solamargine in human K562 leukemia cells. Toxicol In Vitro 24(6):1504–1511PubMedCrossRefGoogle Scholar
  132. Sun L, Zhao Y, Yuan H, Li X, Cheng A, Lou H (2011) Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells. Cancer Chemother Pharmacol 67(4):813–821PubMedCrossRefGoogle Scholar
  133. Thorne HV, Clarke GF, Skuce R (1985) The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids. Antiviral Res 5(6):335–343PubMedCrossRefGoogle Scholar
  134. Tropicos Org (2011) Nomenclatural and specimen database of the Missouri Botanical Garden.
  135. Van Wyk B, Gericke N (2000) People’s plants. A guide to useful plants of Southern Africa. Briza Publications, Pretoria, 351 ppGoogle Scholar
  136. Varshney IP, Sharma SC (1965) Saponins and ­sapogenins-XXIX: The sapogenin of Solanum nigrum L. berries. Phytochemistry 4(6):967–968CrossRefGoogle Scholar
  137. Wang W, Lu DP (2005) An in vitro study of cytotoxic and antineoplastic effect of Solanum nigrum L extract on U266. Beijing Da Xue Xue Bao 37(3):240–244 (In Chinese)PubMedGoogle Scholar
  138. Wang LY, Wang NL, Yao XS (2007) Non-saponins from Solanum nigrum L. Zhong Yao Cai 30(7):792–794 (In Chinese)PubMedGoogle Scholar
  139. Wang HC, Wu DH, Chang YC, Li YJ, Wang CJ (2010) Solanum nigrum Linn. water extract inhibits metastasis in mouse melanoma cells in vitro and in vivo. J Agric Food Chem 58(22):11913–11923PubMedCrossRefGoogle Scholar
  140. Wang HC, Chung PJ, Wu CH, Lan KP, Yang MY, Wang CJ (2011) Solanum nigrum L. polyphenolic extract inhibits hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis. J Sci Food Agric 91(1):178–185PubMedCrossRefGoogle Scholar
  141. Wannang NN, Anuka JA, Kwanashie HO, Gyang SS, Auta A (2008) Anti-seizure activity of the aqueous leaf extract of Solanum nigrum Linn (Solanaceae) in experimental animals. Afr Health Sci 8(2):74–79PubMedGoogle Scholar
  142. Watt JM, Breyer-Brandwijk MG (1962) The medicinal and poisonous plants of southern and eastern Africa, 2nd edn. E. and S. Livingstone, Edinburgh, 1457 ppGoogle Scholar
  143. Xu Y, Pan RL, Chang Q, Qin M, Liu Y, Tang JT (2008) Experimental study of Solanum nigrum on inhibiting angiogenesis in chick chorioallantoic membrane. Zhongguo Zhong Yao Za Zhi 33(5):549–552, In ChinesePubMedGoogle Scholar
  144. Yang MY, Hsu LS, Peng CH, Shi YS, Wu CH, Wang CJ (2010) Polyphenol-rich extracts from Solanum nigrum attenuated PKC alpha-mediated migration and invasion of hepatocellular carcinoma cells. J Agric Food Chem 58(9):5806–5814PubMedCrossRefGoogle Scholar
  145. Yen GC, Chen HY, Peng HH (2001) Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of emerging edible plants. Food Chem Toxicol 39(11):1045–1053PubMedCrossRefGoogle Scholar
  146. Youn YN, Lim E, Lee N, Kim YS, Koo MS, Choi SY (2008) Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro. Gen Nutr 2(4):375–380CrossRefGoogle Scholar
  147. Zakaria ZA, Gopalan HK, Zainal H, Mohd Pojan NH, Morsid NA, Aris A, Sulaiman MR (2006) Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models. Yakugaku Zasshi 126(11):1171–1178PubMedCrossRefGoogle Scholar
  148. Zakaria ZA, Sulaiman MR, Morsid NA, Aris A, Zainal H, Pojan NH, Kumar GH (2009) Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models. Methods Find Exp Clin Pharmacol 31(2):81–88PubMedCrossRefGoogle Scholar
  149. Zhang ZY, Lu AM, D’Arcy WG (1994) Solanaceae A. L. Jussieu. In: Wu ZY, Raven PH, Hong DY (eds) Flora of China, vol 17 (Verbenaceae through Solanaceae). Science Press/Missouri Botanical Garden Press, Beijing/St. LouisGoogle Scholar
  150. Zhao Y, Liu F, Lou HX (2010) Studies on the chemical constituents of Solanum nigrum. Zhong Yao Cai 33(4):555–556 (In Chinese)PubMedGoogle Scholar
  151. Zhou X, He X, Wang G, Gao H, Zhou G, Ye W, Yao X (2006) Steroidal saponins from Solanum nigrum. J Nat Prod 69(8):1158–1163PubMedCrossRefGoogle Scholar
  152. Zhou XL, He XJ, Zhou GX, Ye WC, Yao XS (2007) Pregnane glycosides from Solanum nigrum. J Asian Nat Prod Res 9(6–8):517–523PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.CanberraAustralia

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