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The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches

  • Sabine Hünten
  • Helge Siemens
  • Markus Kaller
  • Heiko Hermeking
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 774)

Abstract

In the recent years, microRNAs (miRNAs) were identified as important components of the signaling cascades that mediate and regulate tumor suppression exerted by p53. This review illustrates some of the main principles that underlie the mechanisms by which miRNAs participate in p53’s function and how they were identified. Furthermore, the current status of the research on the connection between p53 and miRNAs, as well as alterations in the p53/miRNA pathways found in cancer will be summarized and discussed. In addition, experimental and bioinformatics approaches, which can be applied to study the connection between p53 and miRNAs are described. Although, some of the central miRNA-encoding genes that mediate the effects of p53, such as the miR-34 and miR-200 families, have been identified, many additional analyses remain to be performed to fully elucidate the connections between p53 and miRNAs.

Keywords

p53 microRNA miRNA Tumor suppression SILAC Next generation sequencing Genome-wide analysis miR-34 miR-34a miR-34b/c 

Notes

Acknowledgements

We thank the members of the Hermeking Lab for discussions, and Ralf Zimmer and Florian Erhard for advice concerning Fig. 5.6. Work in Heiko Hermeking’s lab is supported by the German Israel Science Foundation (GIF), the Rudolf-Bartling-Stiftung, the Deutsche Krebshilfe and the Deutsche Forschungsgemeinschaft (DFG).

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Sabine Hünten
    • 1
  • Helge Siemens
    • 1
  • Markus Kaller
    • 1
  • Heiko Hermeking
    • 1
  1. 1.Experimental and Molecular Pathology, Institute of PathologyLudwig-Maximilians-Universität MünchenMunichGermany

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