Web Resources for microRNA Research

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 774)

Abstract

Over the last decade thousands of microRNAs (miRNAs) have been discovered in all kinds of taxa. The ever growing number of identified miRNA genes required ordered cataloging and annotation. This has led to the development of miRNA web resources.

MiRNA web resources can be referred to either as web accessible databases (repositories) or web applications that provide a defined computational task upon user request. Today, more than three dozen web accessible resources exist that gather, organize and annotate all kinds of miRNA related data. According to the type of data or data processing method, these miRNA web resources can be classified as miRNA sequence and annotation databases, resources and tools for predicted as well as experimentally validated targets, databases of miRNA regulation and expression, functional annotation and mapping databases and a number of other tools and resources that are species-specific or focus on particular phenotypes.

This chapter provides an overview of the different types of miRNA web resources and their purpose and gives some examples for each category. Furthermore, some valuable miRNA web applications will be introduced. Finally, strategies for miRNA data retrieval and associated risks and pitfalls will be discussed.

Keywords

microRNA sequence database miRNA targets miRNA function miRNA expression Data retrieval Data integration Data mining 

Notes

Acknowledgements

The work of US and OW was supported by the German research foundation (DFG, Project: WO 991/4-1) and the German Federal Ministry of Education and Research (BMBF) as part of the project e:Bio-Metsys. We would like to thank Michael Hecker for fruitful discussions on this topic as well as Julio Vera and Xin Lai for continuous mutual encouragement and for proof reading the manuscript.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Systems Biology and Bioinformatics, Institute of Computer ScienceUniversity of RostockRostockGermany
  2. 2.Stellenbosch Institute for Advanced Study (STIAS)Wallenberg Research Centre at Stellenbosch UniversityStellenboschSouth Africa

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