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Control of Iron Metabolism in Bacteria

  • Simon Andrews
  • Ian Norton
  • Arvindkumar S. Salunkhe
  • Helen Goodluck
  • Wafaa S. M. Aly
  • Hanna Mourad-Agha
  • Pierre Cornelis
Chapter
Part of the Metal Ions in Life Sciences book series (MILS, volume 12)

Abstract

Bacteria depend upon iron as a vital cofactor that enables a wide range of key metabolic activities. Bacteria must therefore ensure a balanced supply of this essential metal. To do so, they invest considerable resourse into its acquisition and employ elaborate control mechanisms to eleviate both iron-induced toxitiy as well as iron deficiency. This chapter describes the processes that bacteria engage in maintaining iron homeostasis. The focus is Escherichia coli, as this bacterium provides a well studied example. A summary of the current status of understanding of iron management at the ‘omics’ level is also presented.

Keywords

ferritin Fur iron regulation iron transport metallome metalloproteome RyhB 

Abbreviations

ABC

ATP-binding cassette

ATP

adenosine 5¢-triphosphate

Bfd

Bfr-associated ferredoxin

Bfr

bacterioferritin

Dps

DNA-binding protein from starved cells

DtxR

diphteria toxin regulator

ECF

extracytoplasmic function

EPR

electron paramagnetic resonance

Fbp

ferric binding protein

Ftn

ferritin

Fur

ferric uptake regulation protein

GDP

guanosine 5¢-diphosphate

GTP

guanosine 5¢-triphosphate

H-NS

histone-like nucleoid structuring protein

IM

inner membrane

IRT

iron-regulated transporter

Isd

iron-regulated surface determinant

LPS

lipopolysaccharide

NEAT

NEAr (iron) transporter

Nramp

natural resistance-associated macrophage protein

NRPS

non-ribosomal peptide synthetase

OM

intermembrane

RnR

ribonucleotide reductase

Sod

superoxide dismutase

sRNA

small regulatory RNA

Tat

twin arginine translocation

TCA

tricarboxylic acid cycle

Tbp

transferrin-binding protein

ZIP

ZRT,IRT-like proteins

ZRT

zinc-regulated transporters

Notes

Acknowledgments

We thank the University of Reading, Diamond Light Source Ltd, the Felix Foundation, the Egyptian Government, and the Nigerian Institute of Medical Research for studentship funding.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Simon Andrews
    • 1
  • Ian Norton
    • 1
  • Arvindkumar S. Salunkhe
    • 1
  • Helen Goodluck
    • 1
  • Wafaa S. M. Aly
    • 1
  • Hanna Mourad-Agha
    • 1
  • Pierre Cornelis
    • 2
  1. 1.The School of Biological SciencesThe University of ReadingReadingUK
  2. 2.Department of Bioengineering Sciences, Research Group Microbiology, Flanders Interuniversity Institute of Biotechnology VIB6Vrije Universiteit BrusselBrusselsBelgium

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