Abstract
Magnesium, the second most abundant cation within the cell, plays an important role in numerous biological functions. Experimental evidence indicates that mammalian cells tightly regulate cellular magnesium ion content through specific mechanisms controlling Mg2+ entry and efflux across the cell membrane and the membrane of various cellular organelles as well as intracellular Mg2+ buffering under resting conditions and following hormonal and metabolic stimuli. This chapter will provide an assessment of the various mechanisms controlling cellular Mg2+ homeostasis and transport, and the implications changes in cellular Mg2+ content play under physiological and pathological conditions.
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- [Mg2+]0 :
-
extracellular Mg2+ concentration
- [Mg2+]i :
-
cytosolic free Mg2+ concentration
- 2,3-DPG:
-
2,3-diphosphoglycerate
- 2-APB:
-
2-2-aminoethyldiphenyl-borate
- AC:
-
adenylyl cyclase
- ACDP2:
-
ancient conversed domain protein 2
- ADP:
-
adenosine 5’-diphosphate
- AMP:
-
adenosine monophosphate
- AP-1:
-
adaptin protein 1
- ATP:
-
adenosine 5’-triphosphate
- Bapta-AM:
-
1,2-bis-(o-Aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid, tetraacetoxymethyl ester
- BK channel:
-
big potassium channel
- CaM:
-
calmodulin
- cAMP:
-
cyclic-adenosine monophosphate
- CaSR:
-
calcium-sensing receptor
- CHAK:
-
channel kinase
- CRAC channel:
-
calcium release-activated Ca2+ channel
- CREB:
-
cAMP response element binding
- DAG:
-
diacyl glycerol
- DHHC:
-
Asp-His-His-Cys motif
- DIDS:
-
4,4’-diisothiocyano-2,2’-stilbenedisulfonic acid
- DNDS:
-
4,4’-dinitrostilbene-2,2’-disulfonic acid
- EDTA:
-
ethylenediamine-N,N,N’,N’-tetraacetate
- eEF2-k:
-
eEF2 cognate kinase
- EGF:
-
epidermal growth factor
- ER:
-
endoplasmic reticulum
- ERK:
-
extracellular responsive kinase
- EXPMA:
-
electron probe X-ray microanalysis
- FHHNC:
-
familial hypomagenesemia with hypercalciuria and nephrocalcinosis
- G6Pase:
-
glucose 6-phosphatase
- G6Pi:
-
glucose 6-phosphate
- GTP:
-
guanosine 5’-triphosphate
- HIP:
-
huntingtin-interacting protein
- HSH:
-
hypomagnesemia with secondary hypocalemia
- HSP:
-
hereditary spastic paraplegia
- IC50 :
-
inhibitory dose achieving 50% inhibition
- IMAC:
-
inner membrane anion channel
- IP3:
-
1,4,5, inositol-trisphophate
- IRH:
-
isolated recessive renal hypomagnesemia
- Mag-Fura:
-
5-oxazolecarboxylic acid, 2-[5-[2-[(acetyloxy)methoxy]-2-oxoethoxy]-6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-2-benzofuranyl]-(acetyloxy)methyl ester
- MagT1:
-
magnesium transporter 1
- MAPK:
-
mitogen-activated protein kinase 1
- MDCT cells:
-
mouse distal convoluted tubule cells
- MDKC cells:
-
Madin-Darby canine kidney cells
- MEK:
-
MAP (erk1/2) kinase kinase
- MIC channel:
-
Mg2+-inhibited cation channel
- MMgT:
-
membrane Mg2+ transporter
- MSK:
-
musculoskeletal
- NIPA:
-
non-imprinted in Prader-Willi/Angelman syndrome
- OMIM:
-
Online Mendelian Inheritance in Man
- OST:
-
oligosaccharide transferase
- PCLN-1:
-
paracellin-1 = claudin 16
- PG1:
-
polygalacturonase 1
- PI3K:
-
phosphoinositide-3-kinase
- PIP2:
-
phosphatidyl-inositol bisphohate
- PKA:
-
protein kinase A
- PKC:
-
protein kinase C
- PLC:
-
phospholipase C
- PMA:
-
phorbol-myristate acetate
- PTP:
-
permeability transition pore
- Q10:
-
Q10 temperature coefficient
- RACK:
-
receptor for activated protein kinase C
- REA:
-
repressor of estrogen receptor activity
- RyR:
-
ryanodine receptor
- SCN:
-
sodium cyanide
- SDS:
-
sodium dodecyl sulfate
- siRNA:
-
short inhibitory RNA molecule
- SLC41:
-
solute carrier family 41
- SOC:
-
store-operated channel
- SR:
-
sarcoplasmic reticulum
- SERCA:
-
sarcoplasmic-endoplasmic reticulum calcium pump
- TRPM6:
-
transient receptor potential melastatin subfamily, isoform 6
- TRPM7:
-
transient receptor potential melastatin subfamily, isoform 7
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Romani, A.M.P. (2013). Magnesium Homeostasis in Mammalian Cells. In: Banci, L. (eds) Metallomics and the Cell. Metal Ions in Life Sciences, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5561-1_4
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