Thiamine Deficiency Complicating the Treatment of Primary CNS Lymphoma

  • Simon E. Richardson
  • Christopher McNamara
Part of the Tumors of the Central Nervous System book series (TCNS, volume 9)


Patients undergoing high-dose chemotherapy for CNS lymphomas are predisposed to thiamine deficiency. With the presence of pre-existing neurological deficits and the lack of a definitive diagnostic test the complications of Wernicke’s encephalopathy and Korsakoff’s dementia are easily missed. Clinicians should be aware of thiamine deficiency as a differential diagnosis for neurological or cardio­vascular deterioration is PCNSL patients. We propose that prophylactic, parenteral thiamine should be administered to all patients receiving second-line anti-emetic therapy during high-dose chemotherapy for CNS malignancy.


Thiamine Deficiency Pyloric Stenosis Thiamine Pyrophosphate Medial Thalamus Beri Beri 
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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of HaematologyThe Royal Free HospitalLondonUK

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