Thiamine Deficiency Complicating the Treatment of Primary CNS Lymphoma
Patients undergoing high-dose chemotherapy for CNS lymphomas are predisposed to thiamine deficiency. With the presence of pre-existing neurological deficits and the lack of a definitive diagnostic test the complications of Wernicke’s encephalopathy and Korsakoff’s dementia are easily missed. Clinicians should be aware of thiamine deficiency as a differential diagnosis for neurological or cardiovascular deterioration is PCNSL patients. We propose that prophylactic, parenteral thiamine should be administered to all patients receiving second-line anti-emetic therapy during high-dose chemotherapy for CNS malignancy.
KeywordsThiamine Deficiency Pyloric Stenosis Thiamine Pyrophosphate Medial Thalamus Beri Beri
- Antunez E, Estruch R, Cardenal C, Nicolas J, Fernandez-Sola J, Urbano-Marquez A (1998) Usefulness of CT and MR imaging in the diagnosis of acute Wernicke’s encephalopathy. Am J Roentgenol 171:1131–1137Google Scholar