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Thiamine Deficiency Complicating the Treatment of Primary CNS Lymphoma

  • Simon E. Richardson
  • Christopher McNamara
Chapter
Part of the Tumors of the Central Nervous System book series (TCNS, volume 9)

Abstract

Patients undergoing high-dose chemotherapy for CNS lymphomas are predisposed to thiamine deficiency. With the presence of pre-existing neurological deficits and the lack of a definitive diagnostic test the complications of Wernicke’s encephalopathy and Korsakoff’s dementia are easily missed. Clinicians should be aware of thiamine deficiency as a differential diagnosis for neurological or cardio­vascular deterioration is PCNSL patients. We propose that prophylactic, parenteral thiamine should be administered to all patients receiving second-line anti-emetic therapy during high-dose chemotherapy for CNS malignancy.

Keywords

Thiamine Deficiency Pyloric Stenosis Thiamine Pyrophosphate Medial Thalamus Beri Beri 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of HaematologyThe Royal Free HospitalLondonUK

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