Abstract
Several biomarkers have been identified as prognostic factors in primary central nervous system lymphoma (PCNSL). As a part of biomarkers, immunostaining for CD10, BCL-6, and MUM-1 has been widely investigated to determine the histogenetic origin of diffuse large B-cell lymphoma of PCNSL. B-cell lymphomas are able to be categorized into three known subtypes: germinal center B-cell (GCB), activated-GCB, and post-GCB subtypes according to immunostaining for these three markers. However, the correlation between immunophenotypic profile of PCNSL and the response to therapy is still unclear. The response to induction high-dose methotrexate therapy has been also identified as a prognostic factor of PCNSL. This review focuses on the immunohistochemistry for BCL-6 and the response to induction high-dose methotrexate therapy as prognostic factors of PCNSL.
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Momota, H. (2012). Primary CNS Lymphoma: Immunohistochemistry of BCL-6 and Treatment with High-Dose Methotrexate. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 9. Tumors of the Central Nervous System, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5488-1_5
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DOI: https://doi.org/10.1007/978-94-007-5488-1_5
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