Primary Central Nervous System Lymphoma Resulting in Stroke and Leukoencephalopathy

  • Stefan Kiechl
  • Benjamin Matosevic
  • Johann Willeit
Part of the Tumors of the Central Nervous System book series (TCNS, volume 9)


In rare instances primary CNS lymphoma (PCNSL) manifests as an intravascular tumour or shows a diffuse infiltrating phenotype known as “lymphomatosis cerebri”. Intravascular PCNSL presents with multiple cerebral infarcts caused by the occlusion of small- to medium-sized vessels while diffuse infiltrating PCNSL is characterized by progressive white matter lesions translating into behavioural changes and cognitive decline. We describe the clinical and histological peculiarities, key imaging findings, diagnostic challenges and differential diagnoses of these special types of PCNSL, and provide a review of literature cases. Prognosis is generally worse than that of classic PCNSL and critically depends on an early diagnosis.


Progressive Multifocal Leukoencephalopathy Cerebral Amyloid Angiopathy Primary Central Nervous System Lymphoma Progressive Multifocal Leukoencephalopathy Reversible Posterior Leukoencephalopathy Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Stefan Kiechl
    • 1
  • Benjamin Matosevic
    • 1
  • Johann Willeit
    • 1
  1. 1.Department of NeurologyMedical University InnsbruckInnsbruckAustria

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