A Cross-Bridge Model Describing the Mechanoenergetics of Actomyosin Interaction

  • Mari Kalda
  • Pearu Peterson
  • Jüri EngelbrechtEmail author
  • Marko Vendelin


In order to study the mechanical contraction and energy consumption by the cardiomyocytes we further developed an actomyosin model of Vendelin et al. (Ann. Biomed. Eng. 28:629–640, 2000). The model is of a self-consistent Huxley-type and is based on Hill formalism linking the free energy profile of reactions and mechanical force. In several experimental studies it has been shown that the dependency between oxygen consumption and stress-strain area is linear and is the same for isometric and shortening contractions. We analyzed the free energy profiles of actomyosin interaction by changing free energies of intermediate states and activation of different reactions. The model is able to replicate the linear dependence between oxygen consumption and stress-strain area together with other important mechanical properties of a cardiac muscle.


Isometric Contraction Myosin Head Biochemical State Mechanical Contraction Free Energy Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was supported by the European Union through the European Regional Development Fund and by the Estonian Science Foundation (Grant nr. 7344).


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Mari Kalda
    • 1
  • Pearu Peterson
    • 1
  • Jüri Engelbrecht
    • 2
    Email author
  • Marko Vendelin
    • 1
  1. 1.Laboratory of Systems Biology, Institute of CyberneticsTallinn University of TechnologyTallinnEstonia
  2. 2.Centre for Nonlinear Studies, Institute of CyberneticsTallinn University of TechnologyTallinnEstonia

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