A Coupled Chemomechanical Model for Smooth Muscle Contraction
This manuscript presents a chemomechanically coupled three-dimensional model, describing the contractile behavior of smooth muscles. It bases on a strain-energy function, additively decomposed into passive parts and an active calcium-driven part related to the chemical contraction of smooth muscle cells. For the description of the calcium phase the four state cross-bridge model of Hai and Murphy (Am. J. Physiol. 254:C99–106, 1988) has been used. Before the features and applicability of the proposed approach are illustrated in terms of three-dimensional boundary-value problems, the model is validated by experiments on porcine smooth muscle tissue strips.
KeywordsSmooth Muscle Contraction Natural Boundary Condition Smooth Muscle Tissue Contraction Process Smooth Muscle Activation
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