A Mathematical Approach for Studying Ca2+-Regulated Smooth Muscle Contraction

  • Saeil C. Murtada
  • Gerhard A. Holzapfel


Smooth muscle is found in various organs. It has mutual purposes such as providing mechanical stability and regulating organ size. To better understand the physiology and the function of smooth muscle different experimental setups and techniques are available. However, to interpret and analyze the experimental results basic models of smooth muscle are necessary. Advanced mathematical models of smooth muscle contraction further allow, to not, only investigate the experimental behavior but also to simulate and predict behaviors in complex boundary conditions that are not easy or even impossible to perform through in vitro experiments. In this chapter the characteristic behaviors of vascular smooth muscle, specially those relevant from a biomechanical point of view, and the mathematical models able to simulate and mimic those behaviors are reviewed and studied.


Smooth Muscle Contraction Myosin Filament Muscle Stretch Elastic Serial Element Myosin Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Financial support for SCM was provided through a Project Grant (#20056167, #20094302) from the Swedish Research Council (VR) and the Swedish Heart-Lung Foundation. This support is gratefully acknowledged.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Division Genetic Physiology, Department of Physiology and PharmacologyKarolinska InstitutetStockholmSweden
  2. 2.Institute of Biomechanics, Center of Biomedical EngineeringGraz University of TechnologyGrazAustria
  3. 3.Department of Solid Mechanics, School of Engineering SciencesRoyal Institute of Technology (KTH)StockholmSweden

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