In Vivo Validation of Predictive Models for Bone Remodeling and Mechanobiology
In silico modeling is a powerful tool for the prediction of bone remodeling and mechanobiology. As the method is gaining popularity a standardized measure for the in vivo validation of the quality of the produced simulations is required. In this review, we discuss current validity assessment approaches, as well as the validation ‘gold standard’, in which the experimental and computational parts are carried out concomitantly, and by the same research team. A novel validation framework for the tissue level model, based on the true geometry is introduced.
KeywordsFracture Healing Strain Energy Density Bone Adaptation Morphometric Index Bone Mineralization Density Distribution
The authors gratefully acknowledge funding from the European Union for the Osteoporotic Virtual Physiological Human project (VPHOP FP7-ICT2008-223865) and computational time from the Swiss National Supercomputing Center (CSCS, Manno, Switzerland).
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