Multicompartmental Poroelasticity as a Platform for the Integrative Modeling of Water Transport in the Brain
This work proposes the implementation of a multiple-network poroelastic theory (MPET) model for the purpose of investigating in detail the transport of water within the cerebral environment. The key advantage of using the MPET representation is that it accounts for fluid transport between CSF, brain parenchyma and cerebral blood. A further novelty in the model is the amalgamation of anatomically accurate Choroid Plexus regions, with their individual feeding arteries. This model is used to demonstrate and discuss the impact of aqueductal stenosis on the cerebral ventricles, along with possible future treatment techniques.
KeywordsChoroid Plexus Fourth Ventricle Endoscopic Third Ventriculostomy Ventricular System Central Canal
This study is supported by the Digital Economy Programme; a Research Councils UK cross-Council initiative led by EPSRC and contributed to by AHRC, ESRC, and MRC. The EPSRC is further acknowledged for providing the resources necessary for the High Performance Computing simulations conducted in this study. The ESI Group and Dr. M. Megahed are kindly acknowledged for allowing the use of the CFD-ACE+ multiphysics suite.
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