Cardiovascular Tissue Damage: An Experimental and Computational Framework

  • Nele Famaey
  • Ellen Kuhl
  • Gerhard A. Holzapfel
  • Jos Vander Sloten


Tissue overload during medical procedures can lead to severe complications. This chapter presents an experimental and computational framework to define and predict damage due to mechanical loading and applies this framework to arterial clamping. An extension of the Holzapfel-material model for arterial tissue is presented, incorporating smooth muscle cell activation and damage to the different constituents. It is implemented in a finite element framework and used to simulate arterial clamping and subsequent damage evaluation through an isometric contraction test. These simulations are compared to actual experiments and repeated for a different clamp design, thereby demonstrating the capability of the framework.


Smooth Muscle Cell Collagen Fiber Maximum Principal Stress Damage Variable Myosin Head 
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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Nele Famaey
    • 1
  • Ellen Kuhl
    • 2
  • Gerhard A. Holzapfel
    • 3
    • 4
  • Jos Vander Sloten
    • 1
  1. 1.Biomechanics SectionKU LeuvenHeverleeBelgium
  2. 2.Department of Mechanical EngineeringStanfordUSA
  3. 3.Institute of Biomechanics, Center of Biomedical EngineeringGraz University of TechnologyGrazAustria
  4. 4.Department of Solid Mechanics, School of Engineering SciencesRoyal Institute of Technology (KTH)StockholmSweden

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