Abstract
In cell biology and regenerative medicine, there is a certain need to modify or manipulate cells, for example within the field of tissue engineering or gene therapy.
Laser radiation allows the precise manipulation and imaging of cells with subcellular resolution. However, high numerical aperture objectives have to be used, to achieve spatial localization and confinement of the laser radiation. Thereby, cell throughput is limited. A possible technology to achieve a similar confinement of laser radiation can be the employment of plasmonic resonances. Using noble metals so-called surface plasmons, being collective electron oscillations at the surface of nanostructures or nanoparticles, can be excited by the laser radiation. Within the near field of these plasmons, the high field intensities can be used to achieve manipulation or characterization of biological processes within a cell.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Vogel A, Venugopalan V (2003) Mechanisms of pulsed laser ablation of biological tissues. Chem Rev 103(2):577–644
Arnold CL, Heisterkamp A, Ertmer W, Lubatschowski H (2008) Computational model for nonlinear plasma formation in high NA micromachining of transparent materials and biological cells. Opt Express 15(16):10304–10317
Williams F, Varma S, Hillenius S (1976) Liquid water as a lone-pair amorphous semiconductor. J Chem Phys 64(4):1549–1554
Koenig K, Riemann I, Fischer P, Halbhuber K (1999) Intracellular nanosurgery with near infrared femtosecond laser pulses. Cell Mol Biol 45:192–201
Kumar S, Maxwell IZ, Heisterkamp A, Polte TR, Lele T, Salanga M, Mazur E, Ingber DE (2006) Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization and extracellular matrix mechanics. Biophys J 90:3762–3773
Tirlapur UK, Koenig K (2002) Targeted transfection by femtosecond laser. Nature 418:290–291
Stevenson D, Agate B, Tsampoula X, Fischer P, Brown CTA, Sibbet W, Riches A, Gunn-Moore F, Dholakia K (2006) Femtosecond optical transfection of cells: viability and efficiency. Opt Express 14:7125–7133
Baumgart J, Bintig W, Ngezahayo A, Willenbrock S, Murua Escobar H, Ertmer W, Lubatschowski H, Heisterkamp A (2008) Quantified femtosecond laser based opto-perforation of living GFSHR-17 and MTH53a cells. Opt Express 16(5):3021–3031
Mie G (1908) Optical properties of colloidal gold solutions. Ann Phys 25:329
Kelly KL, Coronado E, Zhao L, Schatz GC (2003) The optical properties of metal nanoparticles: the influence of size, shape, and dielectric environment. J Phys Chem B 107:668–677
Nedyalkov NN, Atanasov PA, Obara M (2007) Near-field properties of a gold nanoparticle array on different substrates excited by a femtosecond laser. Nanotechnology 18:305703, 1–7
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Heisterkamp, A., Schomaker, M., Heinemann, D. (2013). Application of Plasmonics in Biophotonics: Laser and Nanostructures for Cell Manipulation. In: Di Bartolo, B., Collins, J. (eds) Nano-Optics for Enhancing Light-Matter Interactions on a Molecular Scale. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5313-6_14
Download citation
DOI: https://doi.org/10.1007/978-94-007-5313-6_14
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-5312-9
Online ISBN: 978-94-007-5313-6
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)