Application of Plasmonics in Biophotonics: Laser and Nanostructures for Cell Manipulation

  • Alexander Heisterkamp
  • M. Schomaker
  • D. Heinemann
Conference paper
Part of the NATO Science for Peace and Security Series B: Physics and Biophysics book series (NAPSB)


In cell biology and regenerative medicine, there is a certain need to modify or manipulate cells, for example within the field of tissue engineering or gene therapy.

Laser radiation allows the precise manipulation and imaging of cells with subcellular resolution. However, high numerical aperture objectives have to be used, to achieve spatial localization and confinement of the laser radiation. Thereby, cell throughput is limited. A possible technology to achieve a similar confinement of laser radiation can be the employment of plasmonic resonances. Using noble metals so-called surface plasmons, being collective electron oscillations at the surface of nanostructures or nanoparticles, can be excited by the laser radiation. Within the near field of these plasmons, the high field intensities can be used to achieve manipulation or characterization of biological processes within a cell.


Gold Nanoparticles Field Enhancement Lucifer Yellow Human Stem Cell Cell Manipulation 
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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Alexander Heisterkamp
    • 1
    • 2
    • 3
  • M. Schomaker
    • 2
    • 4
  • D. Heinemann
    • 2
    • 4
  1. 1.Institute of Applied OpticsFriedrich-Schiller University JenaJenaGermany
  2. 2.Excellence Cluster REBIRTHHannoverGermany
  3. 3.Department of Biomedical OpticsBiophotonics GroupHannoverGermany
  4. 4.Laser Zentrum Hannover e.V.HannoverGermany

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