Surgery for Brain Metastasis

  • Douglas L. Stofko
  • Robert J. Weil
  • Steven A. TomsEmail author
Part of the Cancer Metastasis - Biology and Treatment book series (CMBT, volume 18)


Brain metastases (BM) are by far the most common intracranial adult tumor, diagnosed in approximately 150,000–170,000 cancer patients annually in the United States. Due to recent advances in the management of systemic cancers patient survival has increased, with a consequent increase in the incidence of BM. It is estimated that 20–40% of all patients with systemic malignancies harbor cerebral metastases during their life. With the increased incidence due to prolonged patient survival, more patients are being considered for surgical resection. Although surgical management of BM has been performed since the turn of the twentieth century, early results were discouraging and viewed with much doubt. Therefore, treatments for BM were limited to corticosteroids and whole brain radiotherapy until the last few decades. With recent advances in neurosurgical technique, neuroanesthesia and improved localization techniques, more lesions are surgically accessible and there has been a corresponding decrease in surgical morbidity and mortality. Surgical resection of brain metastases continues to evolve but has already demonstrated ­quality of life benefits as well as increased survival. Currently, surgical resection is considered a key component to the management of BM.


Brain Metastasis Recursive Partitioning Analysis Karnofsky Performance Score Cerebral Metastasis Peritumoral Edema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Douglas L. Stofko
    • 1
  • Robert J. Weil
    • 2
  • Steven A. Toms
    • 1
    Email author
  1. 1.Division of Neurosciences, Department of NeurosurgeryGeisinger Medical CenterDanvilleUSA
  2. 2.Department of Neurosurgery and the Neurological InstituteBurkhardt Brain Tumor and Neuro-oncology Center, Cleveland Clinic FoundationClevelandUSA

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