Abstract
TREK channels are background or leak potassium channels that are extensively expressed in the central, somatic peripheral and as recently demonstrated in the autonomic nervous system, where they are thought to play an important role in the modulation of neuronal excitability. Contrary to the expected behavior of “classic leak channels”, the channel activity can be strongly regulated by a number of physiological and non-physiological stimuli (physical, chemical or electrical). In fact, the TREK subfamily can be distinguished from other two-pore-domain potassium channels (K2P) by sensitivity to mechanical stimulation, suggesting an important role for this subfamily in the transduction of touch and pain. Our current understanding of the properties and functions of TREK channels is largely derived from the study of heterologously expressed channels, since the analysis of native K2P channels in real neurons is hampered by the difficulties in isolating specific channel subtypes in complex systems. The aim of this chapter is to summarize our current knowledge of TREK channels, paying particular attention to data obtained from natively expressed channels and from the autonomic nervous system.
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Aller MI, Wisden W (2008) Changes in expression of some two-pore domain potassium channel genes (KCNK) in selected brain regions of developing mice. Neuroscience 151:1154–1172
Alloui A, Zimmermann K, Mamet J, Duprat F, Noel J, Chemin J, Guy N, Blondeau N, Voilley N, Rubat-Coudert C, Borsotto M, Romey G, Heurteaux C, Reeh P, Eschalier A, Lazdunski M (2006) TREK-1, a K+ channel involved in polymodal pain perception. EMBO J 25:2368–2376
Bang H, Kim Y, Kim D (2000) TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family. J Biol Chem 275:17412–17419
Bayliss DA, Barrett PQ (2008) Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact. Trends Pharmacol Sci 29:566–575
Blondeau N, Petrault O, Manta S, Giordanengo V, Gounon P, Bordet R, Lazdunski M, Heurteaux C (2007) Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. Circ Res 101:176–184
Blondeau N, Widmann C, Lazdunski M, Heurteaux C (2002) Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 109:231–241
Bockenhauer D, Zilberberg N, Goldstein SAN (2001) KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci 4:486–491
Cadaveira-Mosquera A, Pérez M, Reboreda A, Rivas-Ramírez P, Fernández-Fernández D, Lamas JA (2012) Expression of K2P channels in sensory and motor neurons of the autonomic nervous system. J Mol Neurosci 48:86–96
Cadaveira-Mosquera A, Ribeiro SJ, Reboreda A, Pérez M, Lamas JA (2011) Activation of TREK currents by the neuroprotective agent riluzole in mouse sympathetic neurons. J Neurosci 31:1375–1385
Chemin J, Girard C, Duprat F, Lesage F, Romey G, Lazdunski M (2003) Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K + channels. EMBO J 22:5403–5411
Chemin J, Patel A, Duprat F, Zanzouri M, Lazdunski M, Honore E (2005a) Lysophosphatidic acid-operated K + channels. J Biol Chem 280:4415–4421
Chemin J, Patel AJ, Duprat F, Lauritzen I, Lazdunski M, Honore E (2005b) A phospholipid sensor controls mechanogating of the K + channel TREK-1. EMBO J 24:44–53
Chemin J, Patel AJ, Duprat F, Sachs F, Lazdunski M, Honore E (2007) Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch -Eur J Physiol 455:97–103
Cohen A, Ben-Abu Y, Hen S, Zilberberg N (2008) A novel mechanism for human K2P2.1 channel gating. Facilitation of C-type gating by protonation of extracellular histidine residues. J Biol Chem 283:19448–19455
Cohen A, Sagron R, Somech E, Segal-Hayoun Y, Zilberberg N (2009) Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K(2P)2.1 channel. Mol Cell Neurosci 40:382–389
Czirják G, Enyedi P (2002) TASK-3 dominates the background potassium conductance in rat adrenal glomerulosa cells. Mol Endocrinol 16:621–629
Czirják G, Enyedi P (2006) Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels. Mol Pharmacol 69:1024–1032
Danthi S, Enyeart JA, Enyeart JJ (2003) Modulation of native TREK-1 and Kv1.4 K+ channels by polyunsaturated fatty acids and lysophospholipids. J Membr Biol 195:147–164
Dedman A, Sharif-Naeini R, Folgering JH, Duprat F, Patel A, Honore E (2009) The mechano-gated K(2P) channel TREK-1. Eur Biophys J 38:293–303
Deng PY, Xiao Z, Yang C, Rojanathammanee L, Grisanti L, Watt J, Geiger JD, Liu R, Porter JE, Lei S (2009) GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels. Neuron 63:230–243
Dobler T, Springauf A, Tovornik S, Weber M, Schmitt A, Sedlmeier R, Wischmeyer E, Doring F (2007) TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. J Physiol 585:867–879
Duprat F, Lesage F, Patel AJ, Fink M, Romey G, Lazdunski M (2000) The neuroprotective agent riluzole activates the two P domain K+ channels TREK-1 and TRAAK. Mol Pharmacol 57:906–912
Eckert M, Egenberger B, Doring F, Wischmeyer E (2011) TREK-1 isoforms generated by alternative translation initiation display different susceptibility to the antidepressant fluoxetine. Neuropharmacology 61:918–923
Enyeart JJ, Xu L, Danthi S, Enyeart JA (2002) An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1. J Biol Chem 277:49186–49199
Enyedi P, Czirják G (2010) Molecular background of leak K + currents: two-pore domain potassium channels. Physiol Rev 90:559–605
Fernández-Fernández D, Cadaveira-Mosquera A, Reboreda A, Rivas-Ramírez P, Domínguez V, Lamas JA (2011) Expresión de canales K2P y estudio de la corriente activada por riluzol en el ganglio nodoso. SENC Abstracts, SII-P31 http://www.senc2011.com/,
Ferroni S, Valente P, Caprini M, Nobile M, Schubert P, Rapisarda C (2003) Arachidonic acid activates an open rectifier potassium channel in cultured rat cortical astrocytes. J Neurosci Res 72:363–372
Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M (1996) Cloning, functional expression and brain localization of a novel unconventional outward rectifier K + channel. EMBO J 15:6854–6862
Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (1998) A neuronal two P domain K + channel stimulated by arachidonic acid and polyunsaturated fatty acids. EMBO J 17:3297–3308
Franks NP, Honore E (2004) The TREK K2P channels and their role in general anaesthesia and neuroprotection. Trends Pharmacol Sci 25:601–608
Frederickson CJ, Bush AI (2001) Synaptically released zinc: physiological functions and pathological effects. Biometals 14:353–366
Gnatenco C, Han J, Snyder AK, Kim D (2002) Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes. Brain Res 931:56–67
Goldman DE (1943) Potential, impedance and rectification in membranes. J Gen Physiol 3760
Goldstein SAN, Bockenhauer D, O’Kelly I, Zilberberg N (2001) Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2:175–184
Gordon JA, Hen R (2006) TREKing toward new antidepressants. Nat Neurosci 9:1081–1083
Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, Franks NP (2004a) Two-pore-domain K + channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Mol Pharmacol 65:443–452
Gruss M, Mathie A, Lieb WR, Franks NP (2004b) The two-pore-domain K + Channels TREK-1 and TASK-3 are differentially modulated by copper and zinc. Mol Pharmacol 66:530–537
Gu W, Günter S, Jochen RH, Hartmut E, Chiristine KS, Andreas KS, Christian D, Ortrud KS, Jürgen D (2002) Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. J Physiol 539:657–668
Gurney A, Manoury B (2009) Two-pore potassium channels in the cardiovascular system. Eur Biophys J 38:305–318
Han J, Truell J, Gnatenco C, Kim D (2002) Characterization of four types of background potassium channels in rat cerebellar granule neurons. J Physiol 542:431–444
Han J, Gnatenco C, Sladek CD, Kim D (2003) Background and tandem-pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus. J Physiol 546:625–639
Hao J, Raoux M, Azorin N, Despoix-Rodat L, Giamarchi A, Maingret F, Crest M, Coste B, Delmas P (2009) Mechanosensitive cation currents and their molecular counterparts in mammalian sensory neurons. In: Kamkin A, Kiseleva I (ed) Mechanosensitivity of the nervous system. Mechanosensitivity in cell and tissues series, vol. 2. Springer, pp 51–64
Hervieu GJ, Cluderay JE, Gray CW, Green PJ, Ranson JL, Randall AD, Meadows HJ (2001) Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS. Neuroscience 103:899–919
Heurteaux C, Guy N, Laigle C, Blondeau N, Duprat F, Mazzuca M, Lang-Lazdunski L, Widmann C, Zanzouri M, Romey G, Lazdunski M (2004) TREK-1, a K+ channel involved in neuroprotection and general anesthesia. EMBO J 23:2684–2695
Heurteaux C, Lucas G, Guy N, El Yacoubi M, Thümmler S, Peng X-D, Noble F, Blondeau N, Widmann C, Borsotto M, Gobbi G, Vaugeois J-M, Debonnel G, Lazdunski M (2006) Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Nat Neurosci 9:1134–1144
Hodgkin AL, Katz B (1949) The effect of sodium ions on the electrical activity of the giant axon of the squid. J Physiol 108:37–77
Holzer P (2011) Acid sensing by visceral afferent neurones. Acta Physiol (Oxf) 201:63–75
Honore E (2007) The neuronal background K2P channels: focus on TREK1. Nat Rev Neurosci 8:251–261
Honore E, Maingret F, Lazdunski M, Patel AJ (2002) An intracellular proton sensor commands lipid- and mechano-gating of the K+ channel TREK-1. EMBO J 21:2968–2976
Honore E, Patel AJ, Chemin J, Suchyna T, Sachs F (2006) Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci USA 103:6859–6864
Huang D, Yu B (2008) Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. Med Hypotheses 70:618–624
Kang D, Kim D (2006) TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K + channels in dorsal root ganglion neurons. Am J Physiol Cell Physiol 291:C138-C146
Kang D, Choe C, Kim D (2004) Functional expression of TREK-2 in insulin-secreting MIN6 cells. Biochem Biophys Res Commun 323:323–331
Kang D, Choe C, Kim D (2005) Thermosensitivity of the two-pore domain K + channels TREK-2 and TRAAK. J Physiol 564:103–116
Kang D, Han J, Kim D (2006) Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor. Am J Physiol Cell Physiol 291:C649-C656
Kang D, Choe C, Cavanaugh E, Kim D (2007) Properties of single two-pore domain TREK-2 channels expressed in mammalian cells. J Physiol 583:57–69
Kang D, Kim GT, Kim EJ, La JH, Lee JS, Lee ES, Park JY, Hong SG, Han J (2008) Lamotrigine inhibits TRESK regulated by G-protein coupled receptor agonists. Biochem Biophys Res Commun 367:609–615
Kennard LE, Chumbley JR, Ranatunga KM, Armstrong SJ, Veale EL, Mathie A (2005) Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine. Br J Pharmacol 144:821–829
Ketchum KA, Joiner WJ, Sellers AJ, Kaczmarek LK, Goldstein SA (1995) A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376:690–695
Kim D (2003) Fatty acid-sensitive two-pore domain K + channels. Trends Pharmacol Sci 24:648–654
Kim Y, Bang H, Gnatenco C, Kim D (2001a) Synergistic interaction and the role of C-terminus in the activation of TRAAK K + channels by pressure, free fatty acids and alkali. Pflugers Arch -Eur J Physiol 442:64–72
Kim Y, Gnatenco C, Bang H, Kim D (2001b) Localization of TREK-2 K + channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi. Pflugers Arch -Eur J Physiol 442:952–960
Kim JS, Park JY, Kang HW, Lee EJ, Bang H, Lee JH (2005) Zinc activates TREK-2 potassium channel activity. J Pharmacol Exp Ther 314:618–625
Koh SD, Monaghan K, Sergeant GP, Ro S, Walker RL, Sanders KM, Horowitz B (2001) TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmission. J Biol Chem 276:44338–44346
Kucheryavykh LY, Kucheryavykh YV, Inyushin M, Shuba YM, Sanabria P, Cubano LA, Skatchkov SN, Eaton MJ (2009) Ischemia increases TREK-2 channel expression in astrocytes: relevance to glutamate clearance. Open Neurosci J 2:40–47
La JH, Schwartz ES, Gebhart GF (2011) Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon. Neuroscience 186:179–187
Lamas JA (1998) A hyperpolarization-activated cation current (Ih) contributes to resting membrane potential in rat superior cervical sympathetic neurones. Pflugers Arch -Eur J Physiol 436:429–435
Lamas JA (2005) The development of the concept of neuronal resting potential. Fundamental and clinical aspects. Rev Neurol 41:538–549
Lamas JA, Reboreda A, Codesido V (2002) Ionic basis of the resting membrane potential in cultured rat sympathetic neurons. Neuroreport 13:585–591
Lamas JA, Romero M, Reboreda A, Sanchez E, Ribeiro SJ (2009) A riluzole- and valproate-sensitive persistent sodium current contributes to the resting membrane potential and increases the excitability of sympathetic neurones. Pflugers Arch -Eur J Physiol 458:589–599
Lauritzen I, Blondeau N, Heurteaux C, Widmann C, Romey G, Lazdunski M (2000) Polyunsaturated fatty acids are potent neuroprotectors. EMBO J 19:1784–1793
Lauritzen I, Chemin J, Honore E, Jodar M, Guy N, Lazdunski M, Jane PA (2005) Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. EMBO Rep 6:642–648
Lembrechts R, Pintelon I, Schnorbusch K, Timmermans JP, Adriaensen D, Brouns I (2011) Expression of mechanogated two-pore domain potassium channels in mouse lungs: special reference to mechanosensory airway receptors. Histochem Cell Biol 136:371–85
Lesage F (2003) Pharmacology of neuronal background potassium channels. Neuropharmacology 44:1–7
Lesage F, Lazdunski M (2000) Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol 279:F793-F801
Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J (1996a) TWIK-1, a ubiquitous human weakly inward rectifying K + channel with a novel structure. EMBO J 15:1004–1011
Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J (1996b) A pH-sensitive yeast outward rectifier K + channel with two pore domains and novel gating properties. J Biol Chem 271:4183–4187
Lesage F, Maingret F, Lazdunski M (2000a) Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K + channel. FEBS Lett 471:137–140
Lesage F, Terrenoire C, Romey G, Lazdunski M (2000b) Human TREK2, a 2P domain mechano-sensitive K + channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem 275:28398–28405
Li XT, Dyachenko V, Zuzarte M, Putzke C, Preisig-Muller R, Isenberg G, Daut J (2006) The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle. Cardiovasc Res 69:86–97
Lopes CM, Rohacs T, Czirják G, Balla T, Enyedi P, Logothetis DE (2005) PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. J Physiol 564:117–129
Lotshaw DP (2007) Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels. Cell Biochem Biophys 47:209–256
Ma XY, Yu JM, Zhang SZ, Liu XY, Wu BH, Wei XL, Yan JQ, Sun HL, Yan HT, Zheng JQ (2011) External Ba2+ block of the two-pore domain potassium channel TREK-1 defines conformational transition in its selectivity filter. J Biol Chem 286:39813–39822
Maingret F, Fosset M, Lesage F, Lazdunski M, Honore E (1999a) TRAAK is a mammalian neuronal mechano-gated K+ channel. J Biol Chem 274:1381–1387
Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E (1999b) Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 274:26691–26696
Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honore E (2000a) TREK-1 is a heat-activated background K+ channel. EMBO J 19:2483–2491
Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E (2000b) Lysophospholipids open the two-pore domain mechano-gated K + channels TREK-1 and TRAAK. J Biol Chem 275:10128–10133
Maingret F, Honore E, Lazdunski M, Patel AJ (2002) Molecular basis of the voltage-dependent gating of TREK-1, a mechano-sensitive K+ channel. Biochem Biophys Res Commun 292:339–346
Mathie A (2007) Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors. J Physiol 578:377–385
Mathie A, Veale EL (2007) Therapeutic potential of neuronal two-pore domain potassium-channel modulators. Curr Opin Investig Drugs 8:555–562
Mazella J, Petrault O, Lucas G, Deval E, Beraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M (2010) Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol 8 e1000355
Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG (2000) Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch -Eur J Physiol 439:714–722
Meadows HJ, Chapman CG, Duckworth DM, Kelsell RE, Murdock PR, Nasir S, Rennie G, Randall AD (2001) The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K + channels TREK-1 and TRAAK. Brain Res 892:94–101
Medhurst AD, Rennie G, Chapman CG, Meadows H, Duckworth MD, Kelsell RE, Gloger II, Pangalos MN (2001) Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res 86:101–114
Moha ou Maati H, Peyronnet R, Devader C, Veyssiere J, Labbal F, Gandin C, Mazella J, Heurteaux C, Borsotto M (2011) A human TREK-1/HEK cell line: a highly efficient screening tool for drug development in neurological diseases. PLoS One 6 e25602
Murbartian J, Lei Q, Sando JJ, Bayliss DA (2005) Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. J Biol Chem 280:30175–30184
Nicolas MT, Lesage F, Reyes R, Barhanin J, Dememes D (2004) Localization of TREK-1, a two-pore-domain K + channel in the peripheral vestibular system of mouse and rat. Brain Res 1017:46–52
Noël J, Zimmermann K, Busserolles J, Deval E, Alloui A, Diochot S, Guy N, Borsotto M, Reeh P, Eschalier A, Lazdunski M (2009) The mechano-activated K + channels TRAAK and TREK-1 control both warm and cold perception. EMBO J 28:1308–1318
Noël J, Sandoz G, Lesage F (2011) Molecular regulations governing TREK and TRAAK channel functions. Channels (Austin) 5:402–409
Ozaita A, Vega-Saenz de Miera E (2002) Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K + channel gene KCNK4: Chromosomal localization, tissue distribution and functional expression. Mol Brain Res 102:18–27
Patel AJ, Honore E (2001) Properties and modulation of mammalian 2P domain K + channels. Trends Neurosci 24:339–346
Patel AJ, Honore E, Maingret F, Lesage F, Fink M, Duprat F, Lazdunski M (1998) A mammalian two pore domain mechano-gated S-like K + channel. EMBO J 17:4283–4290
Patel AJ, Honore E, Lesage F, Fink M, Romey G, Lazdunski M (1999) Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci 2:422–426
Patel AJ, Lazdunski M, Honore E (2001) Lipid and mechano-gated 2P domain K+ channels. Curr Opin Cell Biol 13:422–428
Perlis RH, Moorjani P, Fagerness J, Purcell S, Trivedi MH, Fava M, Rush AJ, Smoller JW (2008) Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR*D study. Neuropsychopharmacology 33:2810–2819
Plant LD, Rajan S, Goldstein SA (2005) K2P channels and their protein partners. Curr Opin Neurobiol 15:326–333
Pongs O (2009) TREKing noxious thermosensation. EMBO J 28:1195–1196
Putzke C, Wemhoner K, Sachse FB, Rinne S, Schlichthorl G, Li XT, Jae L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-Muller R, Daut J, Decher N (2007) The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res 75:59–68
Reboreda A, Cadaveira-Mosquera A, Rivas-Ramírez P, Fernández-Fernández D, Domínguez V, Lamas JA (2010) Muscarinic modulation of TREK currents in culture mouse superior cervical ganglion neurons. FENS Abstr 5:013–33
Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (1998) Cloning and expression of a novel pH-sensitive two pore domain K + channel from human kidney. J Biol Chem 273:30863–30869
Reyes R, Lauritzen I, Lesage F, Ettaiche M, Fosset M, Lazdunski M (2000) Immunolocalization of the arachidonic acid and mechanosensitive baseline TRAAK potassium channel in the nervous system. Neuroscience 95:893–901
Richter TA, Dvoryanchikov GA, Chaudhari N, Roper SD (2004) Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds. J Neurophysiol 92:1928–1936
Rivas-Ramírez P, Reboreda A, Cadaveira-Mosquera A, Fernández-Fernández D, Domínguez V, Lamas JA (2011) Caracterización de la vía de inhibición muscarínica de corrientes TREK en neuronas del ganglio cervical superior en cultivo. SENC Abstracts, SIII-P33, www.senc2011.com
Romero M, Reboreda A, Sánchez E, Lamas JA (2004) Newly developed blockers of the M-current do not reduce spike frequency adaptation in cultured mouse sympathetic neurons. Eur J Neurosci 19:2693–2702
Sabbadini M, Yost CS (2009) Molecular biology of background K + channels: insights from K2P knockout mice. J Mol Biol 385:1331–1344
Salkoff L, Jegla T (1995) Surfing the DNA databases for K + channels nets yet more diversity. Neuron 15:489–492
Sandoz G, Thummler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F (2006) AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K + channels into open leak channels. EMBO J 25:5864–5872
Sandoz G, Bell SC, Isacoff EY (2011) Optical probing of a dynamic membrane interaction that regulates the TREK1 channel. Proc Natl Acad Sci USA 108:2605–2610
Segal-Hayoun Y, Cohen A, Zilberberg N (2010) Molecular mechanisms underlying membrane-potential-mediated regulation of neuronal K2P2.1 channels. Mol Cell Neurosci 43:117–126
Seifert G, Huttmann K, Binder DK, Hartmann C, Wyczynski A, Neusch C, Steinhauser C (2009) Analysis of astroglial K + channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit. J Neurosci 29:7474–7488
Simkin D, Cavanaugh EJ, Kim D (2008) Control of the single channel conductance of K2P10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation. J Physiol 586:5651–5663
Suh BC, Hille B (2005) Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol 15:370–378
Suh BC, Hille B (2007) Regulation of KCNQ channels by manipulation of phosphoinositides. J Physiol 582:911–916
Talley EM, Solorzano G, Lei Q, Kim D, Bayliss DA (2001) CNS distribution of members of the two-pore-domain (KCNK) potassium channel family. J Neurosci 21:7491–7505
Talley EM, Sirois JE, Lei Q, Bayliss DA (2003) Two-pore-domain (KCNK) potassium channels: dynamic roles in neuronal function. Neuroscientist 9:46–56
Tan JHC, Liu W, Saint DA (2002) Trek-like potassium channels in rat cardiac ventricular myocytes are activated by intracellular ATP. J Membr Biol 185:201–207
Terrenoire C, Lauritzen I, Lesage F, Romey G, Lazdunski M (2001) A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics. Circ Res 89:336–342
Thomas D, Plant LD, Wilkens CM, McCrossan ZA, Goldstein SAN (2008) Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium. Neuron 58:859–870
Thümmler S, Duprat F, Lazdunski M (2007) Antipsychotics inhibit TREK but not TRAAK channels. Biochem Biophys Res Commun 354:284–289
Viana F, de la Peña E, Belmonte C (2002) Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat Neurosci 5:254–260
Voloshyna I, Besana A, Castillo M, Matos T, Weinstein IB, Mansukhani M, Robinson RB, Cordon-Cardo C, Feinmark SJ (2008) TREK-1 is a novel molecular target in prostate cancer. Cancer Res 68:1197–1203
Xiao Z, Deng PY, Rojanathammanee L, Yang C, Grisanti L, Permpoonputtana K, Weinshenker D, Doze VA, Porter JE, Lei S (2009) Noradrenergic depression of neuronal excitability in the entorhinal cortex via activation of TREK-2 K + channels. J Biol Chem 284:10980–10991
Yamamoto Y, Taniguchi K (2006) Expression of tandem P domain K + channel, TREK-1, in the rat carotid body. J Histochem Cytochem 54:467–472
Yamamoto Y, Hatakeyama T, Taniguchi K (2009) Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells. Neurosci Lett 454:129–133
Yang SB, Jan LY (2008) Thrilling moment of an inhibitory channel. Neuron 58:823–824
Zhao H, Sprunger LK, Simasko SM (2010) Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat. Am J Physiol Gastrointest Liver Physiol 298:G212-G221
Zhou M, Xu G, Xie M, Zhang X, Schools GP, Ma L, Kimelberg HK, Chen H (2009) TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. J Neurosci 29:8551–8564
Acknowledgments
Our investigation is currently supported by grants from the Spanish Ministry of Science and Innovation (MICINN BFU2008–02952/BFI and CONSOLIDER-INGENIO CSD2008–00005) and the Galician Government (INBIOMED 2009/063) to JAL. Help from Antonio Reboreda and Alba Cadaveira is gratefully recognized.
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Lamas, J.A. (2012). Mechanosensitive K2P channels, TREKking through the autonomic nervous system. In: Kamkin, A., Lozinsky, I. (eds) Mechanically Gated Channels and their Regulation. Mechanosensitivity in Cells and Tissues, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5073-9_2
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