EBV-Positive Diffuse Large B-Cell Lymphoma of the Elderly

  • Jorge J. Castillo
Part of the Cancer Growth and Progression book series (CAGP, volume 14)


The purpose of this chapter is to provide a thorough summary of the existing knowledge of EBV-positive DLBCL of the elderly. We will discuss the pathogenesis behind EBV-driven malignant transformation of B-cells, the different EBV latency patterns associated with DLBCL, the distinct pathological characteristics of EBV-positive DLBCL, the differential diagnosis of EBV-positive DLBCL, the clinical characteristics of patients with EBV-positive DLBCL of the elderly, the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL, and potential strategies for the treatment of this rare entity.


Hodgkin Lymphoma Overall Response Rate Primary Effusion Lymphoma DLBCL Patient Classical Hodgkin Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Dr. Castillo would like to thank Dr. Roberto N. Miranda from the Division of Hematopathology at MD Anderson Cancer Center in Houston, Texas for providing the pathological images included in this chapter.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.The Warren Alpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Division of Hematology and OncologyThe Miriam HospitalProvidenceUSA

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