Phosphoinositides in Insulin Action and Diabetes

  • Dave Bridges
  • Alan R. Saltiel
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 362)


Phosphoinositides play an essential role in insulin signaling, serving as a localization signal for a variety of proteins that participate in the regulation of cellular growth and metabolism. This chapter will examine the regulation and localization of phosphoinositide species, and will explore the roles of these lipids in insulin action. We will also discuss the changes in phosphoinositide metabolism that occur in various pathophysiological states such as insulin resistance and diabetes.


GLUT4 Translocation Normal Chow Diet White Adipose Tissue Depot Lysosomal Localization GLUT4 Trafficking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to thank Drs. Dara Leto, David Buchner, Binbin Lu, Irit Hochberg and Diane Fingar (University of Michigan), and Dr. Alan Cheng (University of Louisville) for critical discussions and suggestions during the writing of this chapter.


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© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Life Sciences Institute, University of MichiganAnn ArborUSA

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