Phosphoinositides and Cardiovascular Diseases

  • Alessandra Ghigo
  • Alessia Perino
  • Emilio Hirsch
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 362)


Phosphoinositides (PIs), a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol, are established regulators of multiple cellular functions. An increasing amount of evidence has highlighted potential links between PI-mediated signaling pathways and the etiology of many human diseases, including cardiovascular pathologies. This chapter will provide a detailed overview of the peculiar functions of the major cardiovascular PIs in the pathogenesis of atherosclerosis, heart failure, and arrhythmias.


Cardiac Hypertrophy Ventricular Myocytes Cardiomyocyte Apoptosis Atrial Myocytes PIP2 Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Alessandra Ghigo
    • 1
  • Alessia Perino
    • 1
  • Emilio Hirsch
    • 1
  1. 1.Department of Genetics, Biology and BiochemistryUniversity of Torino, Molecular Biotechnology CenterTorinoItaly

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