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How Do Nascent Proteins Emerge from the Ribosome?

  • Ada Yonath
Conference paper
Part of the NATO Science for Peace and Security Series B: Physics and Biophysics book series (NAPSB)

Abstract

The ribosome is the universal cellular “factory” for producing proteins by translating the genetic code. These highly efficient polymerases posses spectacular architecture and inherent mobility, allowing their smooth performance in decoding the genetic information as well as the formation of peptide bonds, elongation of the newly born proteins and their protection (for review see [45] ChemBioChem 10:63–72, 2009).

Keywords

Tunnel Wall Large Ribosomal Subunit Peptide Bond Formation Nascent Protein Exit Tunnel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Thanks are due to all members of the ribosome groups at the Weizmann Institute and the Max Planck Society for their experimental efforts and illuminating discussion. Support was provided by the US National Inst. of Health (GM34360), the German Ministry for Science and Technology (BMBF 05-641EA), GIF 853–2004, Human Frontier Science Program (HFSP) RGP0076/2003 and the Kimmelman Center for Macromolecular Assemblies. AY holds the Martin and Helen Kimmel Professorial Chair. X-ray diffraction data were collected the EMBL and MPG beam lines at DESY; F1/CHESS, Cornell University, SSRL/Stanford University, ESRF/EMBL, Grenoble, BL26/PF/KEK, Japan and 19ID&23ID/APS/Argonne National Laboratory.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of Structural BiologyWeizmann InstituteRehovotIsrael

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