Anthocyanins as Apoptotic Regulators

  • Jairam Vanamala
  • Sridhar Radhakrishnan
  • Lavanya Reddivari
  • Aaron Massey


Bioactive compounds have been used traditionally in different cultures to promote human health. Anthocyanins (ACNs) are one of the most abundant dietary bioactive compounds and are responsible for the bright red, blue and purple colors of fruits and vegetables. There are over 600 different types of ACNs in nature, featuring six common aglycone structures, with different side chains attached. Although ACN bioavailability is low, ACNs and their gut metabolites possess biological activities that positively impact a variety of chronic diseases including cancer. This book chapter provides a brief summary of the synthesis and the bioavailability of ACNs and discusses the molecular mechanisms involved in ACN-induced apoptosis in cell culture, animal models and human clinical studies. Furthermore, ACN metabolism in vivo is also discussed, as the evidence indicates that the ACN meta­bolites are important pro-apoptotic agents. We hope that the presented evidence will help influence future research in the direction of furthering the scientific understanding of ACN pro-apoptotic properties in cancer.


High Performance Liquid Chromatography Aberrant Crypt Focus Familial Adenomatous Polyposis Patient Grape Seed Extract Caffeic Acid Phenethyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Jairam Vanamala
    • 1
    • 2
  • Sridhar Radhakrishnan
    • 1
  • Lavanya Reddivari
    • 3
  • Aaron Massey
    • 1
  1. 1.Department of Food Science and Human NutritionColorado State UniversityFort CollinsUSA
  2. 2.Cancer Chemoprevention SectionUniversity of Colorado Cancer CenterAuroraUSA
  3. 3.Department of Horticulture and Landscape ArchitectureColorado State UniversityFort CollinsUSA

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