Applications of Network Bioinformatics to Cancer Angiogenesis

  • Corban G. Rivera
  • Liang-Hui Chu
  • Joel S. Bader
  • Aleksander S. Popel


Angiogenesis is the formation of new blood vessels from preexisting microvessels. Excessive and insufficient angiogenesis has been associated with many diseases including cancer, age-related macular degeneration, ischemic heart, brain, and skeletal muscle diseases. In this book chapter, we focus on the biological networks associated with angiogenesis in cancer. We review diverse studies on angiogenesis networks, including angiogenic signaling and angiogenic switch networks, global angiogenesis protein-protein interaction networks, crosstalk among angiogenic pathways, and drug networks. This chapter is for readers who are interested in cancer systems biology and bioinformatics, especially in angiogenesis.


Network biology Network bioinformatics Bioinformatics Angio-genesis Angiogenesis signaling networks Protein interaction networks 



Protein-protein interaction


Protein interaction network


Human umbilical vein endothelial cells


Gene ontology


Tumor necrosis factor


Characteristic subpathway network


Vascular endothelial growth factor


Receptor tyrosine kinase


Nuclear factor kappa B




Gene encoding for receptor tyrosine kinase


Estrogen receptor beta


Hypoxia inducible factor 1

MAP Kinase

Mitogen activated protein kinase


Basic fibroblast growth factor


Support vector machines


Myelocytomatosis viral oncogene homolog


Tumor necrosis factor


Clustering techniques for automatic information extraction


Transforming growth factor beta


Epidermal growth factor


Fibroblast growth factor




Kilo Dalton


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Corban G. Rivera
    • 1
    • 2
  • Liang-Hui Chu
    • 1
  • Joel S. Bader
    • 1
    • 2
  • Aleksander S. Popel
    • 1
  1. 1.Department of Biomedical EngineeringJohns Hopkins UniversityBaltimoreUSA
  2. 2.High-Throughput Biology Center, Johns Hopkins School of MedicineJohns Hopkins UniversityBaltimoreUSA

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