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Cancer Stem Cells of the Head and Neck

  • Xu Qian
  • Andreas M. Kaufmann
  • Andreas E. Albers
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 8)

Abstract

The initiation and metastasis of head and neck squamous cell carcinomas (HNSCC) and other cancers have recently been related to the presence of cancer stem cells (CSC). CSC are cancer initiating, sustaining, and reside mostly quiescently in the tumor. Specific markers and stemness-related genes that characterize putative HNSCC-CSC have been identified. Compared to the bulk tumor mass, CSC are less sensitive to chemo- and radiotherapy and may also have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome of HNSCC which has two distinct etiologies: infection of epithelial stem cells by high-risk types of the human papillomavirus, or long-term tobacco and alcohol abuse. Recent knowledge on the role of CSC in HNSCC is reviewed and where necessary parallels to CSC of other origin are drawn to give a more comprehensive picture.

Keywords

Cancer Stem Cell Reactive Oxygen Species Level Normal Stem Cell Cancer Stem Cell Marker Tissue Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Xu Qian
    • 1
  • Andreas M. Kaufmann
    • 2
  • Andreas E. Albers
    • 1
  1. 1.Department of Otolaryngology, Head and Neck SurgeryChaité-Universitätsmedizin BerlinBerlinGermany
  2. 2.Clinic for GynecologyChaité-Universitätsmedizin BerlinBerlinGermany

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