Neuroprotection for Stroke Using Glial Cell Line-Derived Neurotrophic Factor/Neural Stem Cells Grafting
Stroke is the common disease among elder people and leading cause of death in the world, while its treatment strategies are very limited. After acute stroke, the survivors still suffer from disability in most cases, resulting in a huge burden for family and society. Thus substantial advances in the prevention and treatment of stroke are of paramount importance. Grafting neural stem cells (NSCs) as cell replacement for neuronal loss due to ischemia has been demonstrated to improve neurological deficits after stroke, while the efficacy of NSCs after transplantation is compromised by the low survival rate and low neuronal differentiation. It has been shown that modifying niche of grafted NSCs can help to increase the survival rate and neuronal differentiation by infusing neurotrophic factors, such as glial cell-derived neurotrophic factors (GDNF); however, direct GDNF injection by intracerebral administration is not an optimal. Recently, the treatment by using of NSCs with overexpressed GDNF ex vivo has been demonstrated to significantly improve therapeutic efficacy, suggesting that it may be a promising approach for neurodegenerative diseases including stroke.
KeywordsNeurotrophic Factor Middle Cerebral Artery Occlusion Neuronal Differentiation Stroke Model Overlie Cortex
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