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Use of Cancer/Testis Antigens in Immunotherapy: Potential Effect on Mesenchymal Stem Cells

  • Felipe Saldanha-Araujo
  • Rodrigo Haddad
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 8)

Abstract

Currently, the identification of appropriate target antigens is the most critical step for the development of antigen-specific cancer immunotherapy. The cancer testis antigens (CTAs) have emerged as potential targets for cancer therapies due to their expression in a range of malignant cells with low or highly restrict expression in normal tissues. Several clinical trials involving CTAs are now being conducted with some promising results. Conversely, the identification of CTAs expression in normal stem cells, such as mesenchymal stem cells (MSCs), should be considerate in these studies. The possible side effects of CTA-based immunotherapy in MSCs cannot be ignored or overlooked, taking into account their biological properties.

Keywords

Stem Cell Mesenchymal Stem Cell Adult Stem Cell Cancer Vaccine Normal Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Laboratório de Hematologia/Biologia MolecularInstituto Nacional de Células-Tronco e Terapia Celular (INCTC)Ribeirão PretoBrazil
  2. 2.Department of Pediatrics, School of MedicineUniversity of California San DiegoLa JollaUSA

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