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Stem Cells and Cancer Stem Cells, Volume 8 pp 113–119Cite as

Use of Cancer/Testis Antigens in Immunotherapy: Potential Effect on Mesenchymal Stem Cells

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 8))

Abstract

Currently, the identification of appropriate target antigens is the most critical step for the development of antigen-specific cancer immunotherapy. The cancer testis antigens (CTAs) have emerged as potential targets for cancer therapies due to their expression in a range of malignant cells with low or highly restrict expression in normal tissues. Several clinical trials involving CTAs are now being conducted with some promising results. Conversely, the identification of CTAs expression in normal stem cells, such as mesenchymal stem cells (MSCs), should be considerate in these studies. The possible side effects of CTA-based immunotherapy in MSCs cannot be ignored or overlooked, taking into account their biological properties.

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Author information

Authors and Affiliations

  1. Laboratório de Hematologia/Biologia Molecular, Instituto Nacional de Células-Tronco e Terapia Celular (INCTC), Ribeirão Preto, São Paulo, Brazil

    Felipe Saldanha-Araujo

  2. Department of Pediatrics, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0735, USA

    Rodrigo Haddad

Authors
  1. Felipe Saldanha-Araujo
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  2. Rodrigo Haddad
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Corresponding author

Correspondence to Felipe Saldanha-Araujo .

Editor information

Editors and Affiliations

  1. Biology, Kean University, Union, New Jersey, USA

    M.A. Hayat

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Saldanha-Araujo, F., Haddad, R. (2012). Use of Cancer/Testis Antigens in Immunotherapy: Potential Effect on Mesenchymal Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 8. Stem Cells and Cancer Stem Cells, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4798-2_11

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