Theta-Burst Stimulation Induces Long-Term Potentiation During Beta Oscillation, but Not During Epileptic Discharges, in Rat Hippocampal Slices

  • Motoshi Nishimura
  • Kiyohisa Natsume
Conference paper


Rats exhibit several physiological rhythms—θ, β, and γ rhythms, sharp waves, and ripples—that are related to memory processing. They also exhibit pathological epileptic discharges, and these discharges suppress memory processes. What is the difference between rhythms and discharges? The θ, β, and γ rhythms are reproduced in hippocampal slices. Long-term potentiation (LTP) was easily induced during the generation of carbachol-induced β oscillations, whereas it was suppressed during the generation of gabazine-induced epileptic discharges. These results suggest there is a difference in the mechanism of LTP induction between physiological β oscillations and the pathological rhythm of epileptic discharges. Synaptic plasticity is necessary for induction of the rhythm. It is therefore suggested that synaptic plasticity is not supported during epileptic discharges whereas it can be occurred during the physiological rhythm. This difference could differentiate the memory processes of the two rhythms in vivo.


Synaptic Plasticity Memory Process Hippocampal Slice Sharp Wave Schaffer Collateral 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Lisman, J, Redish, A.D.: Prediction, sequences and the hippocampus. Philos Trans R Soc Lond B Biol Sci. 364(1521) (2009) 1193–201.PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Martin, C., Beshelf, J., Kay, L.M.: An olfacto-hippocampal network is dynamically involved in odor-discrimination learning. J Neurophysiol. 98(4) (2007) 2196–205.PubMedCrossRefGoogle Scholar
  3. 3.
    Ramadan, W., Eschenko, O., Sara, S.J.: Hippocampal sharp wave/ripples during sleep for consolidation of associative memory. PLoS One 4(8) (2009) e6697.PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Schnitzler, A. and Gross, J.: Normal and pathological oscillatory communication in the brain. Nature Rev. Neurosci. 6 (2005) 285–296.CrossRefGoogle Scholar
  5. 5.
    Gallassi, R.: Epileptic amnesic syndrome: an update and further considerations. Epilepsia 47 Suppl 2 (2006) 103–5.PubMedCrossRefGoogle Scholar
  6. 6.
    MacIver, M.B., Harris, D.P., Konopacki, J., Roth, S.H., Bland, B.H.: Carbachol induced rhythmical slow wave activity recorded from dentate granule neurons in vitro. Proc West Pharmacol Soc. 29 (1986) 159–61.PubMedGoogle Scholar
  7. 7.
    Arai, J., Natsume, K.: The properties of carbachol-induced beta oscillation in rat hippocampal slices. Neurosci Res. 54(2) (2006) 95–103.PubMedCrossRefGoogle Scholar
  8. 8.
    Fisahn, A., Pike, F., Buhl, E. H. & Paulsen, O.: Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro. Nature 394 (1998) 186–189.PubMedCrossRefGoogle Scholar
  9. 9.
    Sokal, D.M., Mason, R., Parker, T.L.: Multi-neuronal recordings reveal a differential effect of thapsigargin on bicuculline- or gabazine-induced epileptiform excitability in rat hippocampal neuronal networks. Neuropharmacology 39(12) (2000) 2408–17.PubMedCrossRefGoogle Scholar
  10. 10.
    Natsume, K., Kometani, K.: Theta-activity-dependent and -independent muscarinic facilitation of long-term potentiation in guinea pig hippocampal slices. Neurosci. Res. 27 (1997) 335–41.PubMedCrossRefGoogle Scholar
  11. 11.
    Nishimura, M., Hashimoto, A., Natsume, K.: Carbachol-induced beta oscillation and the epileptic discharges in rat hippocampal slices. Neurosci. Res. 65 Suppl 1 (2009) P3–n12.Google Scholar
  12. 12.
    Bains, J.S., Longacher, J.M. & Staley, K.J.: Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses. Nat Neurosci 2 (1999) 720–726.PubMedCrossRefGoogle Scholar
  13. 13.
    Ogata, G., Natsume, K.: The synaptic efficacy modulates the frequency of interictal discharges induced by bicuculline in guinea-pig hippocampal slices. SFN Abstracts (2007) 165.14.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Kyushu Institute of TechnologyFukuokaJapan

Personalised recommendations